INT142872

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.11
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp8) peptidase activity (Casp8) mitochondrion (Casp8)
nucleus (Casp8) protein complex (Casp8) cytoplasm (Casp8)
Anatomy Link Frequency
liver 1
brain 1
cortex 1
hippocampus 1
Casp8 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 7 97.38 Very High Very High Very High
methadone 6 97.08 Very High Very High Very High
cytokine 14 72.92 Quite High
diabetic neuropathy 2 67.36 Quite High
Inflammation 18 64.72 Quite High
Inflammatory response 5 37.00 Quite Low
chemokine 7 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 38 99.76 Very High Very High Very High
Diabetes Mellitus 154 99.36 Very High Very High Very High
Apoptosis 185 98.24 Very High Very High Very High
Cognitive Disorder 7 97.98 Very High Very High Very High
Injury 12 89.32 High High
Stress 4 87.04 High High
Diabetic Neuropathy 2 67.36 Quite High
INFLAMMATION 24 64.72 Quite High
Targeted Disruption 3 62.08 Quite High
Infection 24 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: This study analyzes the effects of prolonged administration of methadone and withdrawal on sensorimotor and cognitive performance in mice and explores the associated changes in brain expression of proteins regulating the extrinsic (FasL, Fas, and caspase-8) and the mitochondrial (Bcl-2, Bcl-x(L), Bad, and Bax) apoptotic pathways.
Regulation (regulating) of caspase-8 in brain associated with cognitive disorder, methadone, apoptosis and withdrawal
1) Confidence 0.29 Published 2007 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 17384938 Disease Relevance 0.35 Pain Relevance 0.26
Up-regulation of FLIP, caspase-8 inhibitor, enhanced NF-?
Regulation (regulation) of caspase-8
2) Confidence 0.18 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.90 Pain Relevance 0.09
Both the chronic methadone and repeated withdrawal groups showed up-regulation of several pro-apoptotic proteins (FasL, the active fragment of caspase-8, and Bad) in the cortex and hippocampus, indicating activation of both the death-receptor and mitochondrial apoptotic pathways.
Regulation (regulation) of caspase-8 in hippocampus
3) Confidence 0.06 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17384938 Disease Relevance 0.08 Pain Relevance 0
The caspase 3 mRNA was down regulated 1.3–1.5 times, whereas caspase 8 was down regulated by 1.5 times in the test cells.
Regulation ( down reg) of caspase 8
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.29 Pain Relevance 0
The levels of Fas expression and caspase 8 activities are the same in infected and uninfected liver cells of mice, but hydroxyl radicals are increased in infected mice [36].
Regulation (levels) of caspase 8 in liver
5) Confidence 0.04 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.40 Pain Relevance 0.04
Both the chronic methadone and repeated withdrawal groups showed up-regulation of several pro-apoptotic proteins (FasL, the active fragment of caspase-8, and Bad) in the cortex and hippocampus, indicating activation of both the death-receptor and mitochondrial apoptotic pathways.
Regulation (regulation) of caspase-8 in cortex
6) Confidence 0.02 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17384938 Disease Relevance 0.08 Pain Relevance 0

General Comments

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