INT142882

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.57
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) signal transduction (IGF1)
extracellular space (IGF1) extracellular region (IGF1) plasma membrane (TRPV1)
Anatomy Link Frequency
SH-SY5Y 2
peripheral nervous system 2
IGF1 (Homo sapiens)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 98.88 Very High Very High Very High
Peripheral nervous system 2 96.20 Very High Very High Very High
Kinase C 2 90.60 High High
qutenza 2 88.60 High High
Disease Link Frequency Relevance Heat
Pain 4 98.88 Very High Very High Very High
Neuroblastoma 4 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system.
IGF-I Positive_regulation (enhance) of Gene_expression (expression) of TRPV1 in peripheral nervous system associated with pain and peripheral nervous system
1) Confidence 0.06 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17385724 Disease Relevance 0.31 Pain Relevance 0.31
Here, we study the long-term effects on TRPV1 expression mediated by insulin-like growth factor type-I (IGF-I) and insulin in a stably TRPV1-expressing SH-SY5Y neuroblastoma cell line.
IGF-I Positive_regulation (mediated) of Gene_expression (expression) of TRPV1 in SH-SY5Y associated with neuroblastoma
2) Confidence 0.04 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17385724 Disease Relevance 0.27 Pain Relevance 0.21

General Comments

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