INT142904

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 9.49
Pain Relevance 6.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges2) cytosol (Ptges2) mitochondrion (Ptges2)
Golgi apparatus (Ptges2) nucleus (Ptges2) DNA binding (Ptges2)
Anatomy Link Frequency
chondrocytes 1
cardiovascular system 1
Ptges2 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 1 99.98 Very High Very High Very High
Inflammation 91 99.50 Very High Very High Very High
Analgesic 5 99.26 Very High Very High Very High
Osteoarthritis 1 99.12 Very High Very High Very High
rheumatoid arthritis 5 98.44 Very High Very High Very High
Pain 37 98.20 Very High Very High Very High
IPN 6 98.12 Very High Very High Very High
cytokine 4 97.72 Very High Very High Very High
cINOD 33 93.96 High High
Inflammatory stimuli 3 92.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 89 99.50 Very High Very High Very High
Multiple Sclerosis 32 99.42 Very High Very High Very High
Osteoarthritis 8 99.12 Very High Very High Very High
Rheumatoid Arthritis 6 98.44 Very High Very High Very High
Pain 21 98.20 Very High Very High Very High
Inflammatory Pain 6 98.12 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.80 Very High Very High Very High
Hypertension 1 97.00 Very High Very High Very High
Thrombosis 1 96.44 Very High Very High Very High
Disease 19 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of mPGES-1, however, renders the PGH(2) substrate available for diversion to other PG synthases.
Negative_regulation (Inhibition) of mPGES-1
1) Confidence 0.47 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20371706 Disease Relevance 0.27 Pain Relevance 0.18
Novel mouse models of selective COX-2 inhibition and disruption of microsomal prostaglandin E synthase-1 have been exploited to reveal the relative importance of prostacyclin and prostaglandin E2 in cardiovascular homeostasis.
Negative_regulation (disruption) of microsomal prostaglandin E synthase-1
2) Confidence 0.32 Published 2007 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 18030055 Disease Relevance 0.46 Pain Relevance 0.16
Inhibitors of microsomal PGE synthase-1 (mPGES-1) are being developed for relief of pain and interest has focused on their potential impact on the cardiovascular system.
Negative_regulation (Inhibitors) of microsomal PGE synthase-1 in cardiovascular system associated with pain
3) Confidence 0.25 Published 2008 Journal J. Intern. Med. Section Abstract Doc Link 18410593 Disease Relevance 0.95 Pain Relevance 0.40
In studies examining rheumatoid arthritis synovial cells and osteoarthritis chondrocytes, treatment with dexamethasone decreased mPGES-1 mRNA and protein expression mediated by proinflammatory cytokines [23,25,27].
Negative_regulation (decreased) of mPGES-1 in chondrocytes associated with rheumatoid arthritis, dexamethasone, osteoarthritis and cytokine
4) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.96 Pain Relevance 0.66
The aim of this study is to understand the binding affinities of reported inhibitors for mPGES-1 and further to design potential new mPGES-1 inhibitors. 3D-QSAR-CoMFA (comparative molecular field analysis) and CoMSIA (comparative molecular similarity indices analysis) - techniques were employed on a series of indole derivatives that act as selective mPGES-1 inhibitors.
Negative_regulation (inhibitors) of mPGES-1
5) Confidence 0.07 Published 2007 Journal J Mol Model Section Abstract Doc Link 17390157 Disease Relevance 0.17 Pain Relevance 0.13
Inhibitors of mPGES-1 may block PGE(2) production and relieve inflammatory symptoms.
Negative_regulation (Inhibitors) of mPGES-1 associated with inflammation
6) Confidence 0.06 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18524979 Disease Relevance 0.38 Pain Relevance 0.29
To test the hypothesis, we evaluated the antipyretic and analgesic properties of a novel and selective mPGES-1 inhibitor, MF63 [2-(6-chloro-1H-phenanthro-[9,10-d]imidazol-2-yl)isophthalonitrile], in animal models of inflammation.
Negative_regulation (inhibitor) of mPGES-1 associated with inflammation and analgesic
7) Confidence 0.05 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18524979 Disease Relevance 0.46 Pain Relevance 0.47
Our data demonstrate that mPGES-1 inhibition leads to effective relief of both pyresis and inflammatory pain in preclinical models of inflammation and may be a useful approach for treating inflammatory diseases.
Negative_regulation (inhibition) of mPGES-1 associated with inflammation, ipn and disease
8) Confidence 0.05 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18524979 Disease Relevance 1.08 Pain Relevance 0.95
MF63 potently inhibited the human mPGES-1 enzyme (IC(50) = 1.3 nM), with a high degree (>1000-fold) of selectivity over other prostanoid synthases.
Negative_regulation (inhibited) of mPGES-1
9) Confidence 0.05 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18524979 Disease Relevance 0.65 Pain Relevance 0.60
In rodent species, MF63 strongly inhibited guinea pig mPGES-1 (IC(50) = 0.9 nM) but not the mouse or rat enzyme.
Negative_regulation (inhibited) of mPGES-1
10) Confidence 0.05 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18524979 Disease Relevance 0.70 Pain Relevance 0.72
Lately, several patents have been generated which target the specific inhibition of the microsomal Prostanglandin E synthase-1 (mPGES-1).
Negative_regulation (inhibition) of mPGES-1
11) Confidence 0.04 Published 2010 Journal Recent Pat CNS Drug Discov Section Abstract Doc Link 19751209 Disease Relevance 0.72 Pain Relevance 0.37
EAE is less severe in mice that lack the microsomal PGE synthase 1 (MPGES-1) gene that codes for the enzyme that synthesizes PGE2 from COX-derived PGH2 [40].
Negative_regulation (lack) of microsomal PGE synthase 1 associated with multiple sclerosis
12) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2873241 Disease Relevance 1.23 Pain Relevance 0.35
Toward the management of inflammation: recent developments of mPGES-1 inhibitors.
Negative_regulation (inhibitors) of mPGES-1 associated with inflammation
13) Confidence 0.03 Published 2010 Journal Recent Pat CNS Drug Discov Section Title Doc Link 19751209 Disease Relevance 0.69 Pain Relevance 0.51
The present review highlights the current state of knowledge of the involvement of mPGES-1 in sickness behaviour and in other inflammation-related disorders and summarizes the recent patents related to mPGES-1 and its specific inhibition.
Negative_regulation (inhibition) of mPGES-1 associated with inflammation
14) Confidence 0.03 Published 2010 Journal Recent Pat CNS Drug Discov Section Abstract Doc Link 19751209 Disease Relevance 0.76 Pain Relevance 0.37

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