INT142906

Context Info Confidence 0.43 First Reported 2007 Last Reported 2008 Negated 0 Speculated 2 Reported most in Body Documents 2 Total Number 4 Disease Relevance 1.82 Pain Relevance 0.49

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)

Anatomy Link Frequency blood 2 vessels 2 Fgf2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Sciatic nerve 6 88.88 diabetic neuropathy 78 88.40 imagery 1 83.60 ischemia 2 75.00 cytokine 21 71.92 anesthesia 1 69.44 Nerve growth factor 42 47.84 neurotrophin 3 42 47.20 hypoalgesia 15 5.00 Hyperalgesia 12 5.00

Disease Link Frequency Relevance Heat Hyperglycemia 6 99.14 Diabetes Mellitus 213 98.48 Diabetic Neuropathy 81 88.40 Increased Venous Pressure Under Development 6 83.20 Cv Unclassified Under Development 2 75.00 Hyperalgesia 15 5.00 Hypoalagesia 15 5.00 Peripheral Arterial Disease 6 5.00 Body Weight 6 5.00 Disease 6 5.00

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Anatomy

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Speculation

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The level of therapeutic vasculogenesis induced by MSC transplantation was similar to that by endothelial progenitor cell transplantation, as we previously reported (16), and the differentiation or incorporation of MSCs to vessels was not observed, suggesting that neovasculalization induced by transplantation would be mediated through the actions of angiogenic factors such as VEGF and bFGF secreted from MSCs, which would explain the improvement of NBF.

Positive_regulation (mediated) of Localization (secreted) of bFGF in vessels

1) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.36 Pain Relevance 0.07

It can be speculated that diabetic conditions such as hyperglycemia and impaired local microcirculation might cause or require the transplanted MSCs to more strongly produce and secrete bFGF and VEGF.

Spec (might) Positive_regulation (require) of Localization (secrete) of bFGF associated with hyperglycemia and diabetes mellitus

2) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.66 Pain Relevance 0.12

It can be speculated that diabetic conditions such as hyperglycemia and impaired local microcirculation might cause or require the transplanted MSCs to more strongly produce and secrete bFGF and VEGF.

Spec (might) Positive_regulation (cause) of Localization (secrete) of bFGF associated with hyperglycemia and diabetes mellitus

3) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.66 Pain Relevance 0.12

In conclusion, sustained release of bFGF using gelatin hydrogel augmented angiogenesis and improved tissue blood flow after excision of the femoral artery.

Positive_regulation (augmented) of Localization (release) of bFGF in blood

4) Confidence 0.31 Published 2007 Journal Heart Vessels Section Abstract Doc Link 17390205 Disease Relevance 0.14 Pain Relevance 0.18

General Comments

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