INT142906

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.82
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
blood 2
vessels 2
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 6 88.88 High High
diabetic neuropathy 78 88.40 High High
imagery 1 83.60 Quite High
ischemia 2 75.00 Quite High
cytokine 21 71.92 Quite High
anesthesia 1 69.44 Quite High
Nerve growth factor 42 47.84 Quite Low
neurotrophin 3 42 47.20 Quite Low
hypoalgesia 15 5.00 Very Low Very Low Very Low
Hyperalgesia 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 6 99.14 Very High Very High Very High
Diabetes Mellitus 213 98.48 Very High Very High Very High
Diabetic Neuropathy 81 88.40 High High
Increased Venous Pressure Under Development 6 83.20 Quite High
Cv Unclassified Under Development 2 75.00 Quite High
Hyperalgesia 15 5.00 Very Low Very Low Very Low
Hypoalagesia 15 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of therapeutic vasculogenesis induced by MSC transplantation was similar to that by endothelial progenitor cell transplantation, as we previously reported (16), and the differentiation or incorporation of MSCs to vessels was not observed, suggesting that neovasculalization induced by transplantation would be mediated through the actions of angiogenic factors such as VEGF and bFGF secreted from MSCs, which would explain the improvement of NBF.
Positive_regulation (mediated) of Localization (secreted) of bFGF in vessels
1) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.36 Pain Relevance 0.07
It can be speculated that diabetic conditions such as hyperglycemia and impaired local microcirculation might cause or require the transplanted MSCs to more strongly produce and secrete bFGF and VEGF.
Spec (might) Positive_regulation (require) of Localization (secrete) of bFGF associated with hyperglycemia and diabetes mellitus
2) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.66 Pain Relevance 0.12
It can be speculated that diabetic conditions such as hyperglycemia and impaired local microcirculation might cause or require the transplanted MSCs to more strongly produce and secrete bFGF and VEGF.
Spec (might) Positive_regulation (cause) of Localization (secrete) of bFGF associated with hyperglycemia and diabetes mellitus
3) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.66 Pain Relevance 0.12
In conclusion, sustained release of bFGF using gelatin hydrogel augmented angiogenesis and improved tissue blood flow after excision of the femoral artery.
Positive_regulation (augmented) of Localization (release) of bFGF in blood
4) Confidence 0.31 Published 2007 Journal Heart Vessels Section Abstract Doc Link 17390205 Disease Relevance 0.14 Pain Relevance 0.18

General Comments

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