INT142908

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Context Info
Confidence 0.38
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 11.46
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FGFR1) extracellular region (FGFR1) cytoplasmic membrane-bounded vesicle (FGFR1)
plasma membrane (FGFR1) nucleus (FGFR1) cytoplasm (FGFR1)
Anatomy Link Frequency
fibroblast 3
thorax 1
abdomen 1
brain 1
HGF 1
FGFR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 72 100.00 Very High Very High Very High
Glutamate 5 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
Spinal cord 4 99.14 Very High Very High Very High
Locus ceruleus 4 98.80 Very High Very High Very High
medulla 7 98.68 Very High Very High Very High
fibrosis 5 98.56 Very High Very High Very High
Inflammation 88 97.88 Very High Very High Very High
Autonomic response 4 89.76 High High
Neurotransmitter 6 89.68 High High
Disease Link Frequency Relevance Heat
Cancer 98 99.68 Very High Very High Very High
Malignant Neoplastic Disease 23 99.64 Very High Very High Very High
Middle Cerebral Artery Infarction 26 99.32 Very High Very High Very High
Stroke 53 98.60 Very High Very High Very High
Fibrosis 4 98.56 Very High Very High Very High
INFLAMMATION 90 97.88 Very High Very High Very High
Pulmonary Disease 47 97.80 Very High Very High Very High
Inflammatory Breast Neoplasms 114 97.54 Very High Very High Very High
Fever 6 97.36 Very High Very High Very High
Death 57 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This includes the release of the nerve growth factor (NGF), VEGF and basic fibroblast growth factor (bFGF) and the modulations of neurotrophic and angiogenic factors gene expression [61].
Localization (release) of basic fibroblast growth factor in fibroblast associated with nerve growth factor
1) Confidence 0.38 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0.51 Pain Relevance 0.19
, as is the case of t-SAM.
Localization (case) of t-SAM
2) Confidence 0.34 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0 Pain Relevance 0
Consequently, FDR for Welch-SAM is not a smooth function of ?
Localization (function) of Welch-SAM
3) Confidence 0.34 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0 Pain Relevance 0
Application of SAM: t-SAM and Welch-SAM
Localization (Application) of Welch-SAM
4) Confidence 0.30 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0 Pain Relevance 0
Application of SAM: t-SAM and Welch-SAM
Localization (Application) of SAM
5) Confidence 0.30 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0 Pain Relevance 0
Application of SAM: t-SAM and Welch-SAM
Localization (Application) of t-SAM
6) Confidence 0.30 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0 Pain Relevance 0
CT thorax/abdomen and OGD were also reported as normal.
Localization (reported) of OGD in thorax
7) Confidence 0.22 Published 2008 Journal Cases J Section Body Doc Link PMC2543002 Disease Relevance 1.34 Pain Relevance 0.15
The development of lymphoedema may be attributed to the high interstitial protein concentration with increased osmotic pressure that causes retention of fluid in the connective tissue [15], and to release of growth factors, in particular vascular endothelial growth factor and basic fibroblast growth factor, that may bring about subcutaneous fibrosis and hyperkeratosis [15,16].


Localization (release) of basic fibroblast growth factor in connective tissue associated with fibrosis and lymphedema
8) Confidence 0.21 Published 2008 Journal AIDS Res Ther Section Body Doc Link PMC2275292 Disease Relevance 0.87 Pain Relevance 0.14
Malignant plasma cells can secrete various cytokines, including VEGF, basic fibroblast growth factor (bFGF), and hepatocyte growth factor (HGF), all known for their pro-angiogenic activity [42].
Localization (secrete) of basic fibroblast growth factor in HGF associated with malignant neoplastic disease and cytokine
9) Confidence 0.16 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.46 Pain Relevance 0.05
Specifically, smooth muscle cell activation and replication in the media may be driven by basic fibroblast growth factor released by injured medial cells, although other unknown growth factors may also be involved.
Localization (released) of basic fibroblast growth factor in medial
10) Confidence 0.15 Published 2008 Journal Clinics Section Body Doc Link PMC2664210 Disease Relevance 0.73 Pain Relevance 0.05
Using Western blotting and immunohistochemistry, PAK1, INI1 and MMP11 protein expression and localization was determined in the contralateral and ipsilateral brain areas of individual stroke patients and rats subjected to MCAO, and in HBMEC and HFN exposed to OGD and reperfusion.


Localization (reperfusion) of OGD in brain associated with middle cerebral artery infarction and stroke
11) Confidence 0.14 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2194693 Disease Relevance 0.53 Pain Relevance 0
CT thorax/abdomen and OGD were also reported as normal.
Localization (reported) of OGD in abdomen
12) Confidence 0.08 Published 2008 Journal Cases J Section Body Doc Link PMC2543002 Disease Relevance 1.34 Pain Relevance 0.15
Recently we have developed new sustained release system of basic fibroblast growth factor (bFGF) using gelatin hydrogel as a carrier.
Localization (release) of basic fibroblast growth factor in fibroblast
13) Confidence 0.04 Published 2007 Journal Heart Vessels Section Abstract Doc Link 17390205 Disease Relevance 0.16 Pain Relevance 0.16
The release of glutamate during OGD and the resulting activation of excito-toxic mechanisms causing neuronal cell death are well documented in this hippocampal slice culture system [17].
Localization (release) of OGD in neuronal associated with glutamate and death
14) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3017519 Disease Relevance 0.49 Pain Relevance 0.20
These phenomena were defined by the results that Go6983 could restore OGD-induced cPKCgamma membrane translocation, but had no further effect on MP-induced inhibition of cPKCgamma membrane translocation.
Localization (translocation) of OGD
15) Confidence 0.04 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18706478 Disease Relevance 0.06 Pain Relevance 0.28
Results for PM2.5 were robust with respect to location of the SAM site because results were comparable when PM2.5 concentrations at individual SAM sites were used as the exposure measure, suggesting that spatial variation in PM2.5 was not a significant source of exposure error for our study participants.
Localization (location) of SAM site
16) Confidence 0.03 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440781 Disease Relevance 0.40 Pain Relevance 0.04
Analysis of IBC tumor cell lines and archival tumor specimens demonstrated that high levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor, IL-6, and IL-8 are expressed and secreted by the tumor cells (unpublished data).
Localization (secreted) of basic fibroblast growth factor in fibroblast associated with inflammatory breast neoplasms and cancer
17) Confidence 0.03 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 2.06 Pain Relevance 0.33
Noradrenergic centers in the brainstem (locus coeruleus) and spinal cord activate the sympathetic adrenomedullary (SAM) release of epinephrine from the adrenal medulla and norepinephrine from the peripheral autonomic nervous system.
Localization (release) of SAM in adrenal medulla associated with medulla, locus ceruleus and spinal cord
18) Confidence 0.02 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 1.50 Pain Relevance 0.84

General Comments

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