INT142941

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 12.20
Pain Relevance 13.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn11a) plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
neurons 3
dorsal root ganglion 2
peripheral nerve 1
Scn11a (Mus musculus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 33 99.68 Very High Very High Very High
Nerve growth factor 32 99.54 Very High Very High Very High
dorsal root ganglion 120 99.52 Very High Very High Very High
trigeminal ganglion 226 99.18 Very High Very High Very High
Pain 405 98.90 Very High Very High Very High
sodium channel 3 98.34 Very High Very High Very High
lidocaine 21 98.20 Very High Very High Very High
Peripheral nerve injury 3 98.12 Very High Very High Very High
tetrodotoxin 9 97.36 Very High Very High Very High
Migraine 22 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 120 99.92 Very High Very High Very High
Sprains And Strains 775 99.68 Very High Very High Very High
Ganglion Cysts 459 99.44 Very High Very High Very High
Pain 439 98.90 Very High Very High Very High
Epilepsy 2 97.34 Very High Very High Very High
Neuroma 36 97.28 Very High Very High Very High
Headache 8 97.24 Very High Very High Very High
Depression 2 96.42 Very High Very High Very High
Nociception 25 95.60 Very High Very High Very High
Neuropathic Pain 375 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of TrpM8 was undetectable, and Mrgprd, Mrgpra1, and Scn11a were markedly reduced.
Negative_regulation (reduced) of Scn11a
1) Confidence 0.43 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.46 Pain Relevance 1.01
That is, all of the methods showed marked down-regulation of Scn10a, Scn11a, Trpa1 and Trpm8 with lesser and variable change in P2rx3 and Trpv1.
Negative_regulation (regulation) of Scn11a
2) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.61 Pain Relevance 0.28
That is, the less the degree of down-regulation of Scn11a, the greater the degree of pain behavior.
Negative_regulation (regulation) of Scn11a associated with pain
3) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.33 Pain Relevance 0.46
The observed correlation is therefore consistent with pain-protected mouse strains showing the greatest level of Scn11a down-regulation.
Negative_regulation (down) of Scn11a associated with pain and sprains and strains
4) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.33 Pain Relevance 0.89
The observed correlation is therefore consistent with pain-protected mouse strains showing the greatest level of Scn11a down-regulation.
Negative_regulation (regulation) of Scn11a associated with pain and sprains and strains
5) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.39 Pain Relevance 0.89
Axotomy induced marked down-regulation of Scn10a, Scn11a, Trpa1 and Trpm8 in all 5 strains with lesser and variable change observed for P2rx3 and Trpv1 (Fig. 1).
Negative_regulation (regulation) of Scn11a associated with sprains and strains
6) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.07 Pain Relevance 0.53
For Scn11a, expression was reduced in all strains, with the degree of reduction minimal in animals that exhibited a high level of ongoing pain behavior and maximal in strains with minimal ongoing pain.
Negative_regulation (reduced) of Scn11a associated with pain and sprains and strains
7) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.00 Pain Relevance 0.59
The TG of Brn3a-/- newborn mice exhibit marked reduction in Trpm8, Mrga1, Mrgd and Scn11a, while CGRP and SP are minimally affected.
Negative_regulation (reduction) of Scn11a associated with calcitonin gene related peptide and trigeminal ganglion
8) Confidence 0.31 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.50 Pain Relevance 0.89
The expression of multiple sensory markers, including Trpa1, TrpC3, Trpm8, Scn11a and several members of the Mrg family, are Runx1-dependent in the DRG.
Negative_regulation (members) of Scn11a
9) Confidence 0.31 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.19 Pain Relevance 0.92
Finally, the approximately 90% reduction of TTXr Na+ currents in injured neurons from mice with a peripheral nerve injury was accompanied with an enhanced tonic block by lidocaine.
Negative_regulation (reduction) of Na in peripheral nerve associated with nervous system injury, lidocaine and peripheral nerve injury
10) Confidence 0.29 Published 2010 Journal Pflugers Arch. Section Abstract Doc Link 20174994 Disease Relevance 0.71 Pain Relevance 1.56
Following nerve injury, a redistribution of Na(v)1.8 from dorsal root ganglion (DRG) neurons into peripheral axons contributes to hyperexcitability and possibly to neuropathic pain.
Negative_regulation (redistribution) of Na in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nervous system injury, neuropathic pain and hyperexcitability
11) Confidence 0.28 Published 2010 Journal Pflugers Arch. Section Abstract Doc Link 20174994 Disease Relevance 0.67 Pain Relevance 0.98
Deletion of Na(v)1.8 resulted in an enhanced tonic block of Na+ currents in DRG neurons held at -80 mV but not at -140 mV.
Negative_regulation (block) of Na in DRG associated with dorsal root ganglion
12) Confidence 0.28 Published 2010 Journal Pflugers Arch. Section Abstract Doc Link 20174994 Disease Relevance 0.88 Pain Relevance 1.45
Expression of mRNAs for SNS and NaN voltage-dependent sodium channels in cultures of DRG neurons is restored by GDNF, whereas NGF is reported to rescue downregulation of SNS, not NaN (Fjell et al. 1999c).
Negative_regulation (downregulation) of NaN in neurons associated with nerve growth factor and sodium channel
13) Confidence 0.08 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.06 Pain Relevance 0.90
These studies show the following: (1) FHM1 mutations produce gain-of-function of the Ca(V)2.1 channel and, as a consequence, increased Ca(V)2.1-dependent neurotransmitter release from cortical neurons and facilitation of in vivo induction and propagation of cortical spreading depression (CSD: the phenomenon underlying migraine aura); (2) FHM2 mutations produce loss-of-function of the alpha2 Na+,K+-ATPase; and (3) the FHM3 mutation accelerates recovery from fast inactivation of Na(V)1.5 (and presumably Na(V)1.1) channels.
Negative_regulation (inactivation) of Na in neurons associated with epilepsy, neurotransmitter, depression and migraine
14) Confidence 0.07 Published 2007 Journal Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Section Abstract Doc Link 17395138 Disease Relevance 0.91 Pain Relevance 0.95
These studies show the following: (1) FHM1 mutations produce gain-of-function of the Ca(V)2.1 channel and, as a consequence, increased Ca(V)2.1-dependent neurotransmitter release from cortical neurons and facilitation of in vivo induction and propagation of cortical spreading depression (CSD: the phenomenon underlying migraine aura); (2) FHM2 mutations produce loss-of-function of the alpha2 Na+,K+-ATPase; and (3) the FHM3 mutation accelerates recovery from fast inactivation of Na(V)1.5 (and presumably Na(V)1.1) channels.
Negative_regulation (inactivation) of Na in neurons associated with epilepsy, neurotransmitter, depression and migraine
15) Confidence 0.06 Published 2007 Journal Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Section Abstract Doc Link 17395138 Disease Relevance 0.92 Pain Relevance 1.02
mice had variable reduction in Na+ current.
Negative_regulation (reduction) of Na
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.17 Pain Relevance 0.06

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