INT142950

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ERCC2) aging (ERCC2) chromosome segregation (ERCC2)
helicase activity (ERCC2) extracellular matrix organization (ERCC2) DNA binding (ERCC2)
Anatomy Link Frequency
EM-2 1
ERCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3 98.08 Very High Very High Very High
rheumatoid arthritis 4 90.44 High High
Pain 1 88.92 High High
Analgesic 4 87.60 High High
cytokine 1 87.16 High High
opioid receptor 1 86.16 High High
Arthritis 2 75.68 Quite High
Root ganglion neuron 1 75.36 Quite High
Neuropathic pain 2 75.00 Quite High
Osteoarthritis 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Disease 1 98.40 Very High Very High Very High
INFLAMMATION 3 98.08 Very High Very High Very High
Herpes Simplex Virus 1 96.76 Very High Very High Very High
Cold Sores 2 95.88 Very High Very High Very High
Rheumatoid Arthritis 4 90.44 High High
Pain 2 88.92 High High
Arthritis 1 75.68 Quite High
Neuropathic Pain 3 75.00 Quite High
Experimental Arthritis 1 75.00 Quite High
Osteoarthritis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We discuss the clinical potential for EM analogues chemically modified to resist proteolytic degradation and identify modified protease-resistant analogues with enhanced bioactivity.
Protein_catabolism (degradation) of EM
1) Confidence 0.25 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20398016 Disease Relevance 0.90 Pain Relevance 0.61
In this study we designed a tripartite synthetic gene to direct production, cleavage, and amidation of EM-2, and placed the endomorphin gene expression cassette in a replication defective Herpes simplex virus (HSV) vector (vEM2).
Protein_catabolism (cleavage) of EM-2 in EM-2 associated with cold sores and herpes simplex virus
2) Confidence 0.21 Published 2007 Journal Pain Section Abstract Doc Link 17395375 Disease Relevance 0.55 Pain Relevance 0.53

General Comments

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