INT142953

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 5.56
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TRPV2) plasma membrane (TRPV2) intracellular (TRPV2)
cytoplasm (TRPV2)
Anatomy Link Frequency
liver 6
TRPV2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 82.64 Quite High
addiction 1 75.00 Quite High
nociceptor 2 74.84 Quite High
Inflammation 4 74.68 Quite High
Pain 5 73.52 Quite High
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 32 99.96 Very High Very High Very High
Cirrhosis 12 99.92 Very High Very High Very High
Chronic Hepatitis 8 99.40 Very High Very High Very High
Cancer 8 97.56 Very High Very High Very High
Neuropathic Pain 4 75.24 Quite High
INFLAMMATION 4 74.68 Quite High
Pain 5 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry of the 55 HCC samples showed that the expression of TRPV2 increased when going from normal liver or chronic hepatitis to cirrhosis.
Positive_regulation (increased) of Gene_expression (expression) of TRPV2 in liver associated with chronic hepatitis, cirrhosis and hepatocellular cancer
1) Confidence 0.70 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 1.40 Pain Relevance 0.09
In HCC, increased expression of TRPV2 was identified in 16/55 (29%) cases.
Positive_regulation (increased) of Gene_expression (expression) of TRPV2 associated with hepatocellular cancer
2) Confidence 0.70 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 1.33 Pain Relevance 0.08
Increased TRPV2 expression was observed in tissues of liver cirrhosis (31/37, 83.8%).
Positive_regulation (Increased) of Gene_expression (expression) of TRPV2 in liver associated with cirrhosis
3) Confidence 0.70 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 1.37 Pain Relevance 0.09
Quantitative RT-PCR and Western blotting analysis revealed that expression of TRPV2 at both the mRNA and protein levels were increased in cirrhotic livers compared with chronic hepatitis, whereas that also occurred in moderately and well-differentiated tumors compared with that of poorly differentiated tumors.
Positive_regulation (increased) of Gene_expression (expression) of TRPV2 in livers associated with chronic hepatitis, cirrhosis and cancer
4) Confidence 0.70 Published 2010 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 20113837 Disease Relevance 1.39 Pain Relevance 0.11
By contrast, expression of human TRPV2 did not lead to detectable activation by either of these stimuli.
Neg (not) Positive_regulation (lead) of Gene_expression (expression) of TRPV2
5) Confidence 0.49 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17395593 Disease Relevance 0.07 Pain Relevance 0.27

General Comments

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