INT142957

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.83
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BACE1) peptidase activity (BACE1) Golgi apparatus (BACE1)
endoplasmic reticulum (BACE1) enzyme binding (BACE1)
Anatomy Link Frequency
cleavage 1
BACE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 198 98.88 Very High Very High Very High
Nav1.1 8 94.32 High High
cINOD 4 44.00 Quite Low
Arthritis 1 41.44 Quite Low
imagery 4 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 3 97.40 Very High Very High Very High
Disease 18 83.16 Quite High
Alzheimer's Dementia 18 81.88 Quite High
Neuroblastoma 6 77.12 Quite High
Amyloid Plaque 1 70.36 Quite High
Targeted Disruption 2 67.36 Quite High
Increased Venous Pressure Under Development 1 45.84 Quite Low
Stress 7 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we and another group found that ADAM10, BACE1, and ?
BACE1 Binding (found) of
1) Confidence 0.37 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0.24 Pain Relevance 0.56
The drug-induced decrease of membrane fluidity correlated with an increased association of APP and its beta-site cleaving enzyme BACE1 with detergent-resistant membranes (DRMs), which represent membrane clusters of substantial rigidity.
BACE1 Binding (association) of
2) Confidence 0.34 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.50 Pain Relevance 0
In our previous studies, we have found that elevated BACE1-mediated cleavage of human Nav?
BACE1 Binding (found) of in cleavage associated with sodium channel
3) Confidence 0.32 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.62
SorL1 has also been shown to interact with BACE1 and it appears to compete with APP for interaction with BACE1 in the Golgi [50].
BACE1 Binding (compete) of
4) Confidence 0.23 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.08 Pain Relevance 0

General Comments

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