INT142958

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.04
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
cleavage 6
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 68.56 Quite High
Arthritis 1 66.00 Quite High
Pain 6 38.48 Quite Low
Central nervous system 10 35.40 Quite Low
Inflammation 17 31.92 Quite Low
aspirin 3 5.00 Very Low Very Low Very Low
intrathecal 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Abeta 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 91 98.16 Very High Very High Very High
Neurodegenerative Disease 4 92.68 High High
Disease 47 86.16 High High
Facial Paralysis 16 84.24 Quite High
Lyme Neuroborreliosis 106 84.04 Quite High
Viral Meningitis 2 74.24 Quite High
Amyloid Plaque 40 73.24 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 71.92 Quite High
Bacterial Meningitis 2 71.60 Quite High
Increased Venous Pressure Under Development 1 70.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, increased degradation of sAPP in neuroinflammation remains a vital possibility.
Positive_regulation (increased) of Protein_catabolism (degradation) of sAPP
1) Confidence 0.55 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 0.35 Pain Relevance 0
According to this hypothesis, both cholesterol and the examined compounds stimulated the beta-secretase cleavage of APP, resulting in a massive increase of secreted amyloid-beta peptides.
Spec (examined) Positive_regulation (stimulated) of Protein_catabolism (cleavage) of APP in cleavage associated with alzheimer's dementia
2) Confidence 0.45 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.57 Pain Relevance 0.10
-secretase-mediated APP cleavage, HEK293T cells were transiently transfected with mammalian expression plasmids encoding wild type APP695myc or APP(T668A)myc, in which Thr668 has been replaced by Ala668.
Positive_regulation (mediated) of Protein_catabolism (cleavage) of APP in cleavage
3) Confidence 0.42 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.14 Pain Relevance 0
In principle, reduced levels of CSF sAPP could be caused by 1) decreased expression of APP, 2) decreased processing of APP into sAPP, 3) decreased clearance of sAPP into CSF, or 4) increased degradation of sAPP.
Positive_regulation (increased) of Protein_catabolism (degradation) of sAPP
4) Confidence 0.37 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 0.98 Pain Relevance 0
42 compared to wt PS1, and differential proteolytic cleavages of its two studied substrates by increasing cleavage of APP after residue 42 (yielding A?
Positive_regulation (increasing) of Protein_catabolism (cleavage) of APP in cleavage
5) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0

General Comments

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