INT142983

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.66
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr3) plasma membrane (S1pr3) signal transducer activity (S1pr3)
S1pr3 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 3 98.48 Very High Very High Very High
Inflammation 12 96.04 Very High Very High Very High
mu opioid receptor 1 85.96 High High
antagonist 2 84.88 Quite High
Morphine 4 81.16 Quite High
agonist 4 79.92 Quite High
chemokine 2 41.68 Quite Low
cytokine 4 40.64 Quite Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Edema 2 97.96 Very High Very High Very High
Disorder Of Lipid Metabolism 137 97.88 Very High Very High Very High
INFLAMMATION 20 96.04 Very High Very High Very High
Cancer 2 95.20 Very High Very High Very High
Increased Venous Pressure Under Development 4 94.40 High High
Sepsis 1 93.36 High High
Adult Respiratory Distress Syndrome 1 92.92 High High
Apoptosis 7 17.92 Low Low
Adhesions 18 5.00 Very Low Very Low Very Low
Atherosclerosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation.
Positive_regulation (transactivation) of S1P3 associated with narcan
1) Confidence 0.57 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Title Doc Link 17395891 Disease Relevance 0.57 Pain Relevance 0.55
This discrepancy was elegantly solved by Nofer et al (2004), which showed that the interaction of ApoA-I with SR-B1 is required for localizing the HDL particles at the membrane level where lysosphingolipids interact with specific receptors as EDG1/3 (also called S1P3) activating several intracellular signaling cascades.
Positive_regulation (called) of S1P3 associated with disorder of lipid metabolism
2) Confidence 0.38 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.09 Pain Relevance 0.03

General Comments

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