INT142984

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Context Info
Confidence 0.70
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 7.90
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr1) plasma membrane (S1pr1) signal transducer activity (S1pr1)
Anatomy Link Frequency
plasma 1
blood 1
lymphocytes 1
lymph 1
stems 1
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 12 99.98 Very High Very High Very High
rheumatoid arthritis 245 99.84 Very High Very High Very High
agonist 73 99.62 Very High Very High Very High
cytokine 57 98.48 Very High Very High Very High
Inflammation 234 98.08 Very High Very High Very High
Arthritis 374 97.88 Very High Very High Very High
Morphine 8 95.52 Very High Very High Very High
cINOD 1 90.16 High High
fibrosis 27 89.92 High High
antagonist 55 88.84 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 245 99.84 Very High Very High Very High
Systemic Sclerosis 6 99.68 Very High Very High Very High
Apoptosis 181 99.36 Very High Very High Very High
Asthma 40 99.26 Very High Very High Very High
Occupational Lung Diseases 2 99.24 Very High Very High Very High
Hypersensitivity 24 98.92 Very High Very High Very High
INFLAMMATION 166 98.08 Very High Very High Very High
Arthritis 416 97.88 Very High Very High Very High
Syndrome 5 97.64 Very High Very High Very High
Mycobacterial Infection 12 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ammit and colleagues [7] firstly demonstrated that S1P levels are elevated in the airways of individuals with asthma after segmental allergen challenge.
Positive_regulation (elevated) of S1P associated with asthma
1) Confidence 0.70 Published 2010 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC3024555 Disease Relevance 1.17 Pain Relevance 0.11
Recently, an involvement of sphingosine-1-phosphate (S1P) in the pathogenesis of allergic bronchial asthma has been suggested by the fact that S1P levels are elevated in the airways of asthmatics [7].
Positive_regulation (elevated) of S1P associated with asthma, hypersensitivity and occupational lung diseases
2) Confidence 0.70 Published 2010 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC3024555 Disease Relevance 0.69 Pain Relevance 0.17
Finally, isoflurane increased the generation of S1P in HK-2 cells.
Positive_regulation (increased) of S1P in HK-2 associated with isoflurane
3) Confidence 0.48 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17898040 Disease Relevance 0.62 Pain Relevance 0.61
These cascade of events include the activation of sphingosine kinase (SK), and subsequent production of the mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P).
Positive_regulation (activation) of S1P
4) Confidence 0.41 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20688834 Disease Relevance 0.78 Pain Relevance 0.24
These results indicate that MNTX provides barrier protection against edemagenic agonists via inhibition of S1P(3) receptor activation and represents a potentially useful therapeutic agent for syndromes of increased vascular permeability.
Positive_regulation (activation) of S1P associated with syndrome, agonist and edema
5) Confidence 0.36 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17395891 Disease Relevance 0.19 Pain Relevance 0.39
Because activation of the sphingosine 1-phosphate receptor, S1P(3), is key to a number of barrier-disruptive responses, we examined the role of this receptor in the permeability response to mOP-R ligation.
Spec (examined) Positive_regulation (activation) of S1P
6) Confidence 0.36 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17395891 Disease Relevance 0.34 Pain Relevance 0.64
The principal mechanism of action of FTY720 is the induction of internalization of S1P receptors (including S1P1/S1PR1, which is highly expressed on T cells circulating in blood and lymph) with subsequent loss of cell response to S1P [21].
Positive_regulation (induction) of S1P in blood
7) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.84 Pain Relevance 0.28
Another line of evidence suggesting a role for S1P in RA stems from studies in which TNF-?
Positive_regulation (role) of S1P in stems associated with rheumatoid arthritis
8) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.32 Pain Relevance 0.21
Additionally, it was shown that the secreted form of S1P also regulated cell survival and apoptosis by its capacity to bind to and activate 5 specific G protein-coupled receptors, S1P1-S1P15 [35].
Positive_regulation (activate) of S1P1-S1P15 associated with apoptosis
9) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.40 Pain Relevance 0.07
Furthermore, genetic studies in mice expressing reduced levels of SPL showed decreased circulating lymphocytes as a result of alterations in lymphocyte trafficking and studies of lymphoid tissues following oral administration of 2-acetyl-4(5)-(1(R), 2(S), 3(R), 4-tetrahydroxybutyl)-imidazole, an experimental inhibitor of SPL, showed a clear relationship between reduced SPL activity, elevated S1P levels, and lower levels of circulating lymphocytes [40], thus supporting the targeting of S1P signaling as a potentially important antiinflammatory pathway [41].
Positive_regulation (elevated) of S1P in lymphocytes associated with inflammation
10) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.34 Pain Relevance 0.15
Similar effects of S1P were also apparent in mice infected with M. smegmatis or M. tuberculosis [36].
Positive_regulation (effects) of S1P associated with mycobacterial infection
11) Confidence 0.25 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.33 Pain Relevance 0.06
It is important to recognize that LPA1,2,3 receptors, at least when expressed heterologously, do show activation to S1P at concentrations in excess of 1 ┬ÁM (Valentine et al., 2008a).
Positive_regulation (activation) of S1P
12) Confidence 0.23 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.08 Pain Relevance 0.16
A recent study using plasma and serum samples from systemic scleroderma patients found elevated LPA and S1P levels.
Positive_regulation (elevated) of S1P in plasma associated with systemic sclerosis
13) Confidence 0.22 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.86 Pain Relevance 0.27
S1P is currently classified as a specific ligand for five cognate receptors, S1P1,2,3,4,5, which are not activated by physiological concentrations of LPA.
Neg (not) Positive_regulation (activated) of S1P1
14) Confidence 0.20 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.07 Pain Relevance 0.20
The principal mechanism of action of FTY720 is the induction of internalization of S1P receptors (including S1P1/S1PR1, which is highly expressed on T cells circulating in blood and lymph) with subsequent loss of cell response to S1P [21].
Positive_regulation (induction) of S1P in lymph
15) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.84 Pain Relevance 0.28

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