INT142986

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.62
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr1) plasma membrane (S1pr1) signal transducer activity (S1pr1)
Anatomy Link Frequency
endothelial cell 1
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 4 98.72 Very High Very High Very High
agonist 4 85.36 High High
Inflammation 12 74.64 Quite High
narcan 3 69.64 Quite High
antagonist 2 65.28 Quite High
mu opioid receptor 1 55.52 Quite High
Inflammatory response 2 51.72 Quite High
Tetrahydrobiopterin 3 48.84 Quite Low
metalloproteinase 6 14.64 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 137 87.44 High High
Death 5 85.12 High High
Apoptosis 7 81.04 Quite High
INFLAMMATION 20 74.64 Quite High
Adhesions 18 73.20 Quite High
Adult Respiratory Distress Syndrome 1 48.52 Quite Low
Atherosclerosis 10 47.88 Quite Low
Sepsis 1 47.64 Quite Low
Increased Venous Pressure Under Development 4 46.96 Quite Low
Cancer 2 45.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine, DAMGO, thrombin, and LPS induced RhoA/ROCK-mediated threonine phosphorylation of S1P(3), which was blocked by MNTX, suggesting S1P(3) transactivation.
Phosphorylation (phosphorylation) of S1P associated with morphine
1) Confidence 0.43 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17395891 Disease Relevance 0 Pain Relevance 0.58
Initially, it was proposed that apolipoproteins A-I and C-I were responsible for the mitogenic effects (Tournier et al 1984; Darbon et al 1986); latest data suggest that lysosphingolipids, namely sphingosine 1-phosphate (S1P), sphingosylphosphorylcholine (SPC), and lysosulfatide (LSF), could also enhance endothelial cell proliferation (Nofer et al 2000; Kimura et al 2001).
Phosphorylation (sphingosylphosphorylcholine) of S1P in endothelial cell
2) Confidence 0.36 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.62 Pain Relevance 0.06

General Comments

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