INT142989

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.72
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr1) plasma membrane (S1pr1) signal transducer activity (S1pr1)
Anatomy Link Frequency
cerebrospinal fluid 1
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 4 98.34 Very High Very High Very High
IPN 1 97.56 Very High Very High Very High
Central nervous system 1 96.80 Very High Very High Very High
Pain 4 87.28 High High
agonist 3 87.12 High High
withdrawal 1 79.12 Quite High
intrathecal 2 77.52 Quite High
narcan 3 68.88 Quite High
antagonist 2 64.52 Quite High
Spinal cord 2 56.56 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 1 97.56 Very High Very High Very High
Apoptosis 1 92.20 High High
Pain 2 87.28 High High
Targeted Disruption 2 85.20 High High
Nociception 4 75.00 Quite High
Adult Respiratory Distress Syndrome 1 47.76 Quite Low
Sepsis 1 46.88 Quite Low
Increased Venous Pressure Under Development 1 46.20 Quite Low
Cancer 1 45.00 Quite Low
INFLAMMATION 1 44.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that S1P concentrations were selectively decreased in the cerebrospinal fluid of adult rats in an acute and an inflammatory pain model.
Negative_regulation (decreased) of S1P in cerebrospinal fluid associated with ipn
1) Confidence 0.43 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18805787 Disease Relevance 0.72 Pain Relevance 0.41
Morphine, DAMGO, thrombin, and LPS induced RhoA/ROCK-mediated threonine phosphorylation of S1P(3), which was blocked by MNTX, suggesting S1P(3) transactivation.
Negative_regulation (blocked) of S1P associated with morphine
2) Confidence 0.22 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17395891 Disease Relevance 0 Pain Relevance 0.58

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox