INT1430

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Context Info
Confidence 0.60
First Reported 1977
Last Reported 2010
Negated 9
Speculated 8
Reported most in Title
Documents 88
Total Number 96
Disease Relevance 16.99
Pain Relevance 60.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
plasma 5
brain 5
ileum 3
jejunum 3
smooth muscle 2
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 473 100.00 Very High Very High Very High
Dynorphin 131 100.00 Very High Very High Very High
Opioid 88 100.00 Very High Very High Very High
Spinal cord 61 100.00 Very High Very High Very High
narcan 61 100.00 Very High Very High Very High
Endogenous opioid 28 100.00 Very High Very High Very High
agonist 28 100.00 Very High Very High Very High
Serotonin 25 100.00 Very High Very High Very High
substance P 21 100.00 Very High Very High Very High
Morphine 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 65 100.00 Very High Very High Very High
Disease 32 99.98 Very High Very High Very High
Bordatella Infection 4 99.84 Very High Very High Very High
Rheumatoid Arthritis 20 99.72 Very High Very High Very High
Pain 148 98.80 Very High Very High Very High
Aging 5 98.56 Very High Very High Very High
Bronchitis 2 98.16 Very High Very High Very High
Glioma 8 98.00 Very High Very High Very High
Arrhythmia Under Development 1 97.80 Very High Very High Very High
Ganglion Cysts 9 97.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the effects of the opioid peptides, beta-endorphin and dynorphin A, on airway smooth muscle function and its possible modulation by tissue peptidases, we studied canine bronchial segments under isometric conditions in vitro.
Spec (possible) Regulation (modulation) of dynorphin in smooth muscle associated with dynorphin and opioid
1) Confidence 0.60 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1977592 Disease Relevance 0 Pain Relevance 0.37
As previous studies have suggested levels of enkephalin and dynorphin are oppositely modulated by DA transmission, we next investigated if DA levels in the striatum were altered by Pten ablation in DA cells.
Regulation (modulated) of dynorphin in striatum associated with dopamine, dynorphin and enkephalin
2) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.81
Examination of the regulation of prodynorphin (pro-DYN) promoter activity is limited by the absence of a good cell model.
Regulation (regulation) of prodynorphin
3) Confidence 0.60 Published 1992 Journal Mol. Endocrinol. Section Abstract Doc Link 1337148 Disease Relevance 0 Pain Relevance 0
This set of cell lines provides a useful model of human origin in which the regulation of the preprodynorphin gene and the posttranslational processing of its products can be studied and compared.
Regulation (regulation) of preprodynorphin gene
4) Confidence 0.57 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1681570 Disease Relevance 0.57 Pain Relevance 0.08
Carrion and colleagues [8,9] showed the binding of DREAM to DNA, which implied a role in the hierarchical machinery regulating the rat dynorphin-encoding prodynorphin (pdyn) gene in a Ca2+-dependent manner.
Regulation (regulating) of dynorphin-encoding prodynorphin associated with dynorphin
5) Confidence 0.56 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.35 Pain Relevance 1.27
Moreover, the wide distribution of leu-enkephalin-IR elements suggests leu-enkephalin control of other diencephalic functions as well.
Regulation (control) of leu-enkephalin associated with enkephalin
6) Confidence 0.56 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12679482 Disease Relevance 0.07 Pain Relevance 0.83
Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.
Regulation (Alterations) of prodynorphin in putamen associated with enkephalin and disease
7) Confidence 0.50 Published 2007 Journal J. Neurosci. Res. Section Title Doc Link 17203488 Disease Relevance 0.55 Pain Relevance 0.38
Parkinson's disease affects differently Met5- and Leu5-enkephalin in the human brain.
Regulation (affects) of Leu5-enkephalin in brain associated with enkephalin and disease
8) Confidence 0.50 Published 1983 Journal Brain Res. Section Title Doc Link 6652499 Disease Relevance 0.19 Pain Relevance 0.63
Carrion and colleagues [8,9] showed the binding of DREAM to DNA, which implied a role in the hierarchical machinery regulating the rat dynorphin-encoding prodynorphin (pdyn) gene in a Ca2+-dependent manner.
Regulation (regulating) of pdyn associated with dynorphin
9) Confidence 0.49 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.35 Pain Relevance 1.27
The effects of leu-enkephalin on the spontaneous and electrically-evoked activity were studied in the longitudinal and circular strips isolated from the duodenum, jejunum and ileum of the cat.
Regulation (effects) of leu-enkephalin in jejunum associated with enkephalin
10) Confidence 0.44 Published 1989 Journal Neuropharmacology Section Abstract Doc Link 2594164 Disease Relevance 0 Pain Relevance 0.43
Vestibular receptors of the frog, Rana temporaria, were examined for the effect of bath-applied opioid peptide leu-enkephalin, its synthetic analogue dalargin and the specific opiate antagonist naloxone.
Spec (examined) Regulation (effect) of leu-enkephalin associated with antagonist, narcan, opiate, enkephalin and opioid
11) Confidence 0.44 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465463 Disease Relevance 0 Pain Relevance 0.92
Effects of leu-enkephalin on the mechanical activity of longitudinal and circular muscles of the small intestine of the cat.
Regulation (Effects) of leu-enkephalin in muscles associated with narcan and enkephalin
12) Confidence 0.44 Published 1989 Journal Neuropharmacology Section Title Doc Link 2594164 Disease Relevance 0 Pain Relevance 0.85
Effects of leu-enkephalin on the mechanical activity of longitudinal and circular muscles of the small intestine of the cat.
Regulation (Effects) of leu-enkephalin in muscles associated with narcan and enkephalin
13) Confidence 0.44 Published 1989 Journal Neuropharmacology Section Title Doc Link 2594164 Disease Relevance 0 Pain Relevance 0.85
The effects of leu-enkephalin on the spontaneous and electrically-evoked activity were studied in the longitudinal and circular strips isolated from the duodenum, jejunum and ileum of the cat.
Regulation (effects) of leu-enkephalin in jejunum associated with enkephalin
14) Confidence 0.44 Published 1989 Journal Neuropharmacology Section Abstract Doc Link 2594164 Disease Relevance 0 Pain Relevance 0.43
[The effect of the synthetic leu-enkephalin analog dalargin on the proliferative activity of glioma C6 cells and on the intensity of their DNA synthesis].
Regulation (effect) of leu-enkephalin associated with narcan, enkephalin and glioma
15) Confidence 0.44 Published 1992 Journal Tsitologiia Section Title Doc Link 1636213 Disease Relevance 0.25 Pain Relevance 0.45
Effect of morphine and leucine-enkephalin on the electrophysiological responses of Pacinian corpuscles of the cat.
Regulation (Effect) of leucine-enkephalin in corpuscles associated with narcan, enkephalin and morphine
16) Confidence 0.44 Published 1983 Journal Neurosci. Lett. Section Title Doc Link 6633946 Disease Relevance 0 Pain Relevance 0.88
[Effect of leu-enkephalin on the verbal forms of mental activity in alcoholics and healthy persons].
Regulation ([Effect) of leu-enkephalin associated with enkephalin
17) Confidence 0.44 Published 1986 Journal Probl Endokrinol (Mosk) Section Title Doc Link 3786302 Disease Relevance 0 Pain Relevance 0.19
[Effect of leu-enkephalin on the verbal forms of mental activity in alcoholics and healthy persons].
Regulation ([Effect) of leu-enkephalin associated with enkephalin
18) Confidence 0.44 Published 1986 Journal Probl Endokrinol (Mosk) Section Title Doc Link 3786302 Disease Relevance 0 Pain Relevance 0.19
Moreover, up-regulation of dynorphin A, which has been shown to be pronociceptive by acting at the bradykinin receptors (B1/2) on primary afferents [24], was linked to Fos expression [25].
Regulation (regulation) of dynorphin associated with dynorphin and bradykinin
19) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.80 Pain Relevance 0.87
Changes in neuropeptide Y, enkephalin, tyrosine hydroxylase, and dynorphin, genes previously shown to be differentially regulated during lactation, provide validation for the microarray analysis.
Regulation (regulated) of dynorphin associated with dynorphin, neuropeptide and enkephalin
20) Confidence 0.44 Published 2005 Journal Endocrinology Section Abstract Doc Link 16002521 Disease Relevance 0.20 Pain Relevance 0.23

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