INT143006

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 26
Disease Relevance 22.92
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (A1BG) molecular_function (A1BG) biological_process (A1BG)
Anatomy Link Frequency
pancreas 7
blood 4
liver 3
hip 1
epithelium 1
A1BG (Homo sapiens)
Pain Link Frequency Relevance Heat
beta blocker 10 93.20 High High
Pain 10 91.28 High High
metalloproteinase 18 83.80 Quite High
cva 6 81.64 Quite High
Chronic pancreatitis 90 80.40 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
Multiple sclerosis 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Neuritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ketoacidosis 8 100.00 Very High Very High Very High
Liver Cancer 18 99.84 Very High Very High Very High
Adenocarcinoma 918 99.28 Very High Very High Very High
Cancer 630 99.16 Very High Very High Very High
Malignant Neoplastic Disease 54 99.12 Very High Very High Very High
Bladder Cancer 18 99.00 Very High Very High Very High
Pancreatic Cancer 288 98.80 Very High Very High Very High
Disorder Of Lipid Metabolism 23 98.00 Very High Very High Very High
Neuromyelitis Optica 81 93.76 High High
Hypertension 46 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis demonstrated elevated protein levels of MMP-9, DJ-1 and A1BG in cancerous pancreatic juice compared with cancer-free pancreatic juice, which is consistent with our proteomic findings.
Gene_expression (levels) of A1BG associated with cancer
1) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.51 Pain Relevance 0
We further confirmed the expression levels of three up-regulated proteins (MMP-9, DJ-1 and A1BG) in pancreatic juice, tissue and serum samples using Western blot, IHC or ELISA.
Gene_expression (expression) of A1BG
2) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.28 Pain Relevance 0.16
As seen in Figure 3, compared with cancer-free controls, increased MMP-9, DJ-1 and A1BG expression in cancerous pancreatic juice were detected by Western blot.
Gene_expression (expression) of A1BG associated with cancer
3) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.68 Pain Relevance 0
The expressions of MMP-9, DJ-1 and A1BG were confirmed by immunohistochemistry in 51 pancreatic cancer and 8 normal pancreas samples that were not included in the proteomic experiment (Table 4; Figure 4).
Gene_expression (expressions) of A1BG in pancreas associated with pancreatic cancer
4) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.88 Pain Relevance 0
The relationships with DJ-1, MMP-9 and A1BG expression and clinicopathological parameters were analyzed using Chi-square or Fisher's exact tests.
Gene_expression (expression) of A1BG
5) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.33 Pain Relevance 0.06
Western blot analysis of MMP-9, DJ-1 and A1BG
Gene_expression (analysis) of A1BG
6) Confidence 0.63 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.73 Pain Relevance 0
To further investigate this issue, our study prospectively follows 157 consecutive primary total hip arthroplasties using the ABG I prosthesis at an average follow-up of 10 years.
Gene_expression (prosthesis) of ABG I in hip
7) Confidence 0.60 Published 2007 Journal J Arthroplasty Section Abstract Doc Link 17400092 Disease Relevance 0.16 Pain Relevance 0.09
Immunohistochemical study showed MMP-9, DJ-1 and A1BG positively expressed in 82.4%, 72.5% and 86.3% of pancreatic cancer tissues, significantly higher than that in normal pancreas tissues.
Gene_expression (expressed) of A1BG in pancreas associated with pancreatic cancer
8) Confidence 0.56 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2528014 Disease Relevance 1.07 Pain Relevance 0.12
Yoon et al. [19] also demonstrated A1BG over-expression in liver cancer cell lines and tissues by semi-quantitative RT-PCR.
Gene_expression (-) of A1BG in liver associated with liver cancer
9) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.35 Pain Relevance 0
Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients

Background

Gene_expression (overexpressed) of A1BG associated with adenocarcinoma
10) Confidence 0.56 Published 2008 Journal BMC Cancer Section Title Doc Link PMC2528014 Disease Relevance 0.80 Pain Relevance 0.03
Our immunohistochemical study further validated that A1BG protein over-expression was seen in most PDAC tissues, but not detected in normal pancreas tissues.
Gene_expression (expression) of A1BG in pancreas associated with adenocarcinoma
11) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.21 Pain Relevance 0
Our immunohistochemical study further validated that A1BG protein over-expression was seen in most PDAC tissues, but not detected in normal pancreas tissues.
Gene_expression (over) of A1BG in pancreas associated with adenocarcinoma
12) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.21 Pain Relevance 0
Our immunohistochemical study further validated that A1BG protein over-expression was seen in most PDAC tissues, but not detected in normal pancreas tissues.
Gene_expression (-) of A1BG in pancreas associated with adenocarcinoma
13) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.21 Pain Relevance 0
Using a glycoprotein profiling method, Kreunin et al. [18] recently found that A1BG was detected in urinary samples from bladder cancer patients, but in none of the samples obtained from non-tumor-bearing individuals.
Neg (none) Gene_expression (detected) of A1BG in bladder associated with cancer and bladder cancer
14) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.23 Pain Relevance 0
Yoon et al. [19] also demonstrated A1BG over-expression in liver cancer cell lines and tissues by semi-quantitative RT-PCR.
Gene_expression (expression) of A1BG in liver associated with liver cancer
15) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.36 Pain Relevance 0
Increased MMP-9, DJ-1 and A1BG expression in cancerous pancreatic juice were confirmed by Western blot.
Gene_expression (expression) of A1BG
16) Confidence 0.56 Published 2008 Journal BMC Cancer Section Abstract Doc Link PMC2528014 Disease Relevance 1.01 Pain Relevance 0.11
Yoon et al. [19] also demonstrated A1BG over-expression in liver cancer cell lines and tissues by semi-quantitative RT-PCR.
Gene_expression (over) of A1BG in liver associated with liver cancer
17) Confidence 0.56 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.35 Pain Relevance 0
It uses ventilator settings and routinely monitored physiological parameters as inputs to produce steady-state estimates of the patient's ABG.
Gene_expression (produce) of ABG
18) Confidence 0.53 Published 2010 Journal Comput Methods Programs Biomed Section Abstract Doc Link 19864039 Disease Relevance 0.32 Pain Relevance 0.12
A1BG was over-expressed in the cytoplasma of malignant epithelia in 86.3% of pancreatic cancer tissues, significantly higher than that in normal pancreas tissues (p < 0.01).


Gene_expression (expressed) of A1BG in pancreas associated with malignant neoplastic disease and pancreatic cancer
19) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.43 Pain Relevance 0.07
A1BG was over-expressed in the cytoplasma of malignant epithelia in 86.3% of pancreatic cancer tissues, significantly higher than that in normal pancreas tissues (p < 0.01).


Gene_expression (-) of A1BG in pancreas associated with malignant neoplastic disease and pancreatic cancer
20) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.43 Pain Relevance 0.07

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