INT14301

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Context Info
Confidence 0.48
First Reported 1973
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 82
Total Number 86
Disease Relevance 67.95
Pain Relevance 8.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
CSF 7
brain 6
granulocyte 6
blood 5
plasma 4
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 368 100.00 Very High Very High Very High
Fibrositis 99 99.92 Very High Very High Very High
Central nervous system 451 99.84 Very High Very High Very High
headache 87 99.58 Very High Very High Very High
Analgesic 36 99.52 Very High Very High Very High
Neuropeptide 15 99.48 Very High Very High Very High
Pain 302 98.48 Very High Very High Very High
substance P 12 96.76 Very High Very High Very High
cytokine 420 96.16 Very High Very High Very High
agonist 14 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 1501 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1298 100.00 Very High Very High Very High
Parkinson's Disease 478 100.00 Very High Very High Very High
INFLAMMATION 402 100.00 Very High Very High Very High
Paralysis 35 100.00 Very High Very High Very High
Cold Sores 13 100.00 Very High Very High Very High
Fibromyalgia 99 99.92 Very High Very High Very High
Neutropenia 146 99.80 Very High Very High Very High
Aging 29 99.80 Very High Very High Very High
Neurodegenerative Disease 94 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In certain diseases the amounts of a given nucleic acid bound by a constant volume of CSF may increase, while in others the amount of such proteins may be reduced.
CSF Binding (bound) of in CSF associated with disease
1) Confidence 0.48 Published 1973 Journal Science Section Abstract Doc Link 4742737 Disease Relevance 0.76 Pain Relevance 0.04
The available data have suggested that GM-CSF is associated with a more wide and potent action on multiple cells, such as neutrophils, monocytes, and intestinal epithelial cells which expressed receptors for GM-CSF.
GM-CSF Binding (associated) of in epithelial cells
2) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 0.36 Pain Relevance 0.09
Despite their chemical differences, all of these molecules interact with the g-csf receptor and initiate downstream signalling through the jak–stat (Janus kinase–signal transducers and activators of transcription) intracellular pathway 79, thus enhancing the activity, production, and release of neutrophils into the peripheral blood.
g-csf Binding (interact) of in blood
3) Confidence 0.43 Published 2008 Journal Current Oncology Section Body Doc Link PMC2259432 Disease Relevance 0.17 Pain Relevance 0
G-CSF produced a rapid increase of neutrophil levels, was well-tolerated, and was associated with only one frequent adverse effect: bone pain.
G-CSF Binding (associated) of in neutrophil associated with pain
4) Confidence 0.42 Published 1989 Journal Semin. Hematol. Section Abstract Doc Link 2471275 Disease Relevance 0.44 Pain Relevance 0.17
Clinical experience with recombinant human granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor.
granulocyte colony-stimulating factor Binding (experience) of in macrophage
5) Confidence 0.37 Published 1989 Journal Semin. Hematol. Section Title Doc Link 2471275 Disease Relevance 0.38 Pain Relevance 0.14
Clinical experience with recombinant human granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor.
granulocyte macrophage colony-stimulating factor Binding (experience) of in macrophage
6) Confidence 0.37 Published 1989 Journal Semin. Hematol. Section Title Doc Link 2471275 Disease Relevance 0.39 Pain Relevance 0.14
Colony-stimulating factor (CSF) was detected both in the patient's serum and in the tumor extracts by a normal human bone marrow culture system.
CSF Binding (detected) of in bone marrow associated with cancer
7) Confidence 0.37 Published 1987 Journal Eur. J. Haematol. Section Abstract Doc Link 3500871 Disease Relevance 0.94 Pain Relevance 0.09
In those with more advanced systemic disease, with or without ADC, CSF HIV responds more slowly to antiviral therapy.


CSF Binding (responds) of associated with acquired immune deficiency syndrome or hiv infection and disease
8) Confidence 0.36 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.31 Pain Relevance 0
The poorly differentiated carcinoma found at autopsy revealed positive immunoreactivity for G-CSF.
G-CSF Binding (immunoreactivity) of associated with carcinoma
9) Confidence 0.35 Published 2008 Journal J Thorac Oncol Section Abstract Doc Link 18758311 Disease Relevance 0.86 Pain Relevance 0.04
Inflammatory disorders of the central nervous system and dementia due to other causes in HIV-seronegative patients were not associated with increased CSF NPY-LI.
CSF Binding (associated) of in central nervous system associated with dementia, inflammation, acquired immune deficiency syndrome or hiv infection and central nervous system
10) Confidence 0.34 Published 1996 Journal J. Neurol. Sci. Section Abstract Doc Link 8815163 Disease Relevance 1.13 Pain Relevance 0.40
Furthermore, in another animal model of IBD (rats treated with 2,4,6-trinitrobenzene sulfonic acid) the pretreatment with G-CSF attenuated both loss of body weight and colonic wall thickening (Egi et al 2003), and this effect was associated with a significant inhibition of IFN?
G-CSF Binding (pretreatment) of in thickening associated with inflammatory bowel disease and body weight
11) Confidence 0.34 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 0.99 Pain Relevance 0.07
Mouth-washings with recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) do not improve grade III-IV oropharyngeal mucositis (OM) in patients with hematological malignancies undergoing stem cell transplantation.
rhGM-CSF Binding (Mouth-washings) of in stem cell associated with mucositis and hematologic neoplasms
12) Confidence 0.33 Published 2002 Journal Bone Marrow Transplant. Section Title Doc Link 12040477 Disease Relevance 0.83 Pain Relevance 0.06
Two retrospective analyses have questioned whether G-CSF may be associated with a higher incidence of immunologic reactions [10, 12].
G-CSF Binding (associated) of
13) Confidence 0.33 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2710993 Disease Relevance 0.43 Pain Relevance 0
Interestingly Xu et al[10] stated that they believed their coverage of the normal CSF was insufficient because they were unable to detect two well known CSF proteins, ?
CSF Binding (coverage) of
14) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881861 Disease Relevance 0.36 Pain Relevance 0.06
He uninterruptedly took G-CSF for about 20 days, with a dose of 5 ?
G-CSF Binding (took) of
15) Confidence 0.32 Published 2008 Journal Cases J Section Body Doc Link PMC2615768 Disease Relevance 0.87 Pain Relevance 0.10
We conclude that G-CSF increases the number of circulating neutrophilic granulocytes in zidovudine-treated patients at relatively low doses and with few side-effects.
G-CSF Binding (increases) of in granulocytes
16) Confidence 0.32 Published 1991 Journal Br. J. Haematol. Section Abstract Doc Link 1714756 Disease Relevance 0.76 Pain Relevance 0.09
Certainly, therapeutic specificity should be emphasized since the various responses to shunt treatment or CSF drainage can only be explained by individual variations in the capacity for CSF production and absorption.
CSF Binding (drainage) of
17) Confidence 0.32 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2615740 Disease Relevance 1.19 Pain Relevance 0.10
As CSF reflects brain metabolism, CSF biomarkers can be used for unraveling pathophysiological mechanisms and for diagnostic purposes.
CSF Binding (metabolism) of in brain
18) Confidence 0.32 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2615740 Disease Relevance 1.01 Pain Relevance 0.09
Comprehensive banking of simultaneously procured CSF and plasma samples for aging/NPH/AD, in conjunction with refinements for brain/CSF image biomarking, should provide the requisite information for delineating neurodegeneration and enhancing the CNS response to various therapeutic modalities.


CSF Binding (samples) of in brain associated with normal pressure hydrocephalus and aging
19) Confidence 0.32 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2615740 Disease Relevance 1.08 Pain Relevance 0
The authors administered recombinant human granulocyte colony-stimulating factor (rhG-CSF) to 16 patients with advanced non-Hodgkin's lymphoma treated with combination chemotherapy.
rhG-CSF Binding (administered) of in granulocyte associated with lymphatic system cancer
20) Confidence 0.32 Published 1990 Journal Cancer Section Abstract Doc Link 1699654 Disease Relevance 0.30 Pain Relevance 0

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