INT143083

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 1.06
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CTLA4) plasma membrane (CTLA4)
Anatomy Link Frequency
osteoclast 1
T-cell 1
CTLA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 6 98.32 Very High Very High Very High
abatacept 10 97.00 Very High Very High Very High
Arthritis 2 96.20 Very High Very High Very High
Inflammation 1 94.68 High High
methotrexate 6 80.84 Quite High
antagonist 2 79.80 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 9 98.32 Very High Very High Very High
Arthritis 1 96.20 Very High Very High Very High
Necrosis 1 96.12 Very High Very High Very High
Cancer 1 95.76 Very High Very High Very High
INFLAMMATION 1 94.68 High High
Juvenile Chronic Polyarthritis 1 76.64 Quite High
Rheumatic Diseases 2 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Effect of CTLA4-Ig on radiographic outcome of patients with rheumatoid arthritis].
Regulation ([Effect) of CTLA4-Ig associated with rheumatoid arthritis
1) Confidence 0.25 Published 2007 Journal Clin Calcium Section Title Doc Link 17404488 Disease Relevance 0.26 Pain Relevance 0.58
[Effect of CTLA4-Ig on radiographic outcome of patients with rheumatoid arthritis].
Regulation ([Effect) of CTLA4-Ig associated with rheumatoid arthritis
2) Confidence 0.25 Published 2007 Journal Clin Calcium Section Title Doc Link 17404488 Disease Relevance 0.26 Pain Relevance 0.58
Abatacept (CTLA4-Ig), the first selective T-cell costimulation modulator has shown to be effective in RA and JIA.
Regulation (effective) of CTLA4-Ig in T-cell
3) Confidence 0.25 Published 2009 Journal Curr Opin Rheumatol Section Body Doc Link 19342956 Disease Relevance 0.15 Pain Relevance 0
Furthermore, CTLA-4 was effective in inhibiting TNF-induced osteoclast formation in a non-T cell dependent TNF-induced model of arthritis as well as the formation of inflammatory bone erosion in vivo.
Regulation (effective) of CTLA-4 in osteoclast associated with inflammation and arthritis
4) Confidence 0.20 Published 2008 Journal Ann. Rheum. Dis. Section Abstract Doc Link 18203760 Disease Relevance 0.38 Pain Relevance 0.20

General Comments

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