INT143091

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 2 100.00 Very High Very High Very High
Hyperalgesia 5 99.00 Very High Very High Very High
antagonist 5 92.72 High High
Glutamate receptor 4 92.24 High High
tetrodotoxin 1 90.88 High High
Calcium channel 1 89.76 High High
Spinal cord 1 81.20 Quite High
agonist 2 76.32 Quite High
Kinase C 2 76.24 Quite High
cerebral cortex 3 75.60 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 99.00 Very High Very High Very High
Apoptosis 5 97.68 Very High Very High Very High
Neurodegenerative Disease 1 75.00 Quite High
Death 1 50.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, inhibition of the NMDA receptor subunit NR2A or NR2B induced a differential short-term versus delayed increase in the apoptosis rate, respectively.
Positive_regulation (induced) of Negative_regulation (inhibition) of NR2B associated with nmda receptor and apoptosis
1) Confidence 0.44 Published 2008 Journal Cereb. Cortex Section Abstract Doc Link 17965127 Disease Relevance 0.56 Pain Relevance 0.39
We also show for the first time that i.t. injection of pSM2 (pShag Magic version 2)-grin2b (coding for an short-hairpin RNA to the NR2B subunit of the NMDAR) resulted in a dose-dependent decrease in the NR2B protein and blockade of hyperalgesia induced by activation of the mGluR1/5 in (S)-3,5-DHPG-treated mice.
Positive_regulation (resulted) of Negative_regulation (decrease) of NR2B associated with hyperalgesia
2) Confidence 0.33 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17405869 Disease Relevance 0.34 Pain Relevance 0.69

General Comments

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