INT143114

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.20
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB4) signal transduction (HLA-DRB4) Golgi apparatus (HLA-DRB4)
endoplasmic reticulum (HLA-DRB4) plasma membrane (HLA-DRB4)
Anatomy Link Frequency
stem cell 2
T cells 2
HLA-DRB4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 111 99.60 Very High Very High Very High
cINOD 11 67.64 Quite High
Inflammation 20 60.84 Quite High
rheumatoid arthritis 9 60.64 Quite High
antagonist 4 60.12 Quite High
agonist 11 39.84 Quite Low
metalloproteinase 2 34.32 Quite Low
fibrosis 1 29.80 Quite Low
Eae 1 28.00 Quite Low
depression 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 95 99.92 Very High Very High Very High
Ductal Carcinoma 2 99.68 Very High Very High Very High
Rheumatoid Arthritis 118 99.60 Very High Very High Very High
Disease 58 99.32 Very High Very High Very High
Cancer 59 98.72 Very High Very High Very High
Reprotox - General 1 11 97.04 Very High Very High Very High
Recurrence 3 95.84 Very High Very High Very High
Death 37 94.68 High High
Myeloid Leukemia 36 89.56 High High
Leukemia 58 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a Spearman Rho correlation test to evaluate correlations between expression of TRAIL and TRAIL receptors on CD4+ T cells in RA patients, we found increased DR4 expression was correlated with an increase in both DR5 and TRAIL (Table 1).
Positive_regulation (increased) of Gene_expression (expression) of DR4 in T cells associated with arthritis
1) Confidence 0.29 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.74 Pain Relevance 0.33
In patients with invasive ductal carcinoma, however, high levels of DR4 expression are positively correlated with tumor grade and with poor prognosis [37].
Positive_regulation (levels) of Gene_expression (expression) of DR4 associated with ductal carcinoma and cancer
2) Confidence 0.19 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.56 Pain Relevance 0.22
However, both cells stained negatively for HLA-class II (HLA-DR) and the hematopoietic marker CD34.
Positive_regulation (negatively) of Neg (negatively) Gene_expression (stained) of HLA-class II
3) Confidence 0.05 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0 Pain Relevance 0
Whereas treatment with R-flurbiprofen or ibuprofen resulted in a massive induction of p75(NTR) protein levels, the expression of Fas, p55(TNFR), DR3, DR4, DR5, and DR6 remained largely unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of DR4
4) Confidence 0.04 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409433 Disease Relevance 0.76 Pain Relevance 0.34
irradiation, stem cell transplantation, and interferon alpha (IFN?)
Positive_regulation (stem cell) of Gene_expression (irradiation) of transplantation in stem cell
5) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.31 Pain Relevance 0.03
VPA-induced apoptosis, via the extrinsic pathway involving engagement of the caspase-8-dependent cascade, sensitizes cells to TRAIL/Apo2L-mediated apoptosis by increasing expression of DR4 and DR5 by 3- and 14-fold, respectively.
Positive_regulation (increasing) of Gene_expression (expression) of DR4 associated with apoptosis
6) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.83 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox