INT143141

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.57
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gaa) lysosome (Gaa)
Anatomy Link Frequency
spleen 3
liver 1
Gaa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 2 76.40 Quite High
imagery 2 45.92 Quite Low
Disease Link Frequency Relevance Heat
Lysosomal Storage Diseases 2 99.60 Very High Very High Very High
Gauchers Disease 4 98.70 Very High Very High Very High
Anaemia 2 83.20 Quite High
Thrombocytopenia 2 82.56 Quite High
Pain 2 76.40 Quite High
Osteoporosis 2 72.64 Quite High
Spontaneous Fractures 2 71.68 Quite High
Necrosis 2 68.64 Quite High
Disease 4 56.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Gaucher disease is the most common lysosomal storage disease and is caused by deficient production and activity of the lysosomal enzyme beta-glucosidase (glucocerebrosidase), resulting in progressive accumulation of glucosylceramide (glucocerebroside) in lysosomes of cells of the reticuloendothelial system in the spleen, liver, and marrow.
Positive_regulation (caused) of Gene_expression (production) of lysosomal enzyme beta-glucosidase in spleen associated with lysosomal storage diseases and gauchers disease
1) Confidence 0.03 Published 2007 Journal J Pediatr Orthop Section Abstract Doc Link 17414023 Disease Relevance 0.79 Pain Relevance 0.08
BACKGROUND: Gaucher disease is the most common lysosomal storage disease and is caused by deficient production and activity of the lysosomal enzyme beta-glucosidase (glucocerebrosidase), resulting in progressive accumulation of glucosylceramide (glucocerebroside) in lysosomes of cells of the reticuloendothelial system in the spleen, liver, and marrow.
Positive_regulation (caused) of in liver Gene_expression (production) of lysosomal enzyme beta-glucosidase in spleen associated with lysosomal storage diseases and gauchers disease
2) Confidence 0.01 Published 2007 Journal J Pediatr Orthop Section Abstract Doc Link 17414023 Disease Relevance 0.79 Pain Relevance 0.08

General Comments

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