INT143143

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.83
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Gba) carbohydrate metabolic process (Gba) lipid metabolic process (Gba)
lysosome (Gba)
Anatomy Link Frequency
spleen 3
liver 1
Gba (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 78.00 Quite High
imagery 2 47.52 Quite Low
Inflammatory response 2 30.08 Quite Low
isoflurane 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lysosomal Storage Diseases 2 99.60 Very High Very High Very High
Gauchers Disease 36 98.70 Very High Very High Very High
Anaemia 4 84.80 Quite High
Thrombocytopenia 4 84.16 Quite High
Pain 4 78.00 Quite High
Osteoporosis 2 74.24 Quite High
Spontaneous Fractures 2 73.28 Quite High
Necrosis 4 70.24 Quite High
Death 10 66.16 Quite High
Disease 20 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the mice receiving the 60 U/kg/wk dose, serum anti-GCase IgG levels increased ?
Positive_regulation (increased) of Gene_expression (levels) of anti-GCase
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.07 Pain Relevance 0
In the mice receiving the 60 U/kg/wk dose, serum anti-GCase IgG levels increased ?
Positive_regulation (serum) of Gene_expression (levels) of anti-GCase
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.07 Pain Relevance 0
BACKGROUND: Gaucher disease is the most common lysosomal storage disease and is caused by deficient production and activity of the lysosomal enzyme beta-glucosidase (glucocerebrosidase), resulting in progressive accumulation of glucosylceramide (glucocerebroside) in lysosomes of cells of the reticuloendothelial system in the spleen, liver, and marrow.
Positive_regulation (caused) of Gene_expression (production) of glucocerebrosidase in spleen associated with lysosomal storage diseases and gauchers disease
3) Confidence 0.10 Published 2007 Journal J Pediatr Orthop Section Abstract Doc Link 17414023 Disease Relevance 0.85 Pain Relevance 0.08
BACKGROUND: Gaucher disease is the most common lysosomal storage disease and is caused by deficient production and activity of the lysosomal enzyme beta-glucosidase (glucocerebrosidase), resulting in progressive accumulation of glucosylceramide (glucocerebroside) in lysosomes of cells of the reticuloendothelial system in the spleen, liver, and marrow.
Positive_regulation (caused) of in liver Gene_expression (production) of glucocerebrosidase in spleen associated with lysosomal storage diseases and gauchers disease
4) Confidence 0.03 Published 2007 Journal J Pediatr Orthop Section Abstract Doc Link 17414023 Disease Relevance 0.85 Pain Relevance 0.08

General Comments

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