INT143158

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 20.62
Pain Relevance 5.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
macrophages 7
epithelial cells 6
alveolar macrophages 5
endometrium 4
monocytes 4
TLR4 (Homo sapiens)
TLR4 - D299G (1)
Pain Link Frequency Relevance Heat
depression 4 100.00 Very High Very High Very High
spinal inflammation 4 100.00 Very High Very High Very High
endometriosis 147 99.78 Very High Very High Very High
Inflammation 428 99.34 Very High Very High Very High
agonist 85 99.32 Very High Very High Very High
Inflammatory response 75 97.96 Very High Very High Very High
cytokine 379 97.68 Very High Very High Very High
rheumatoid arthritis 242 97.64 Very High Very High Very High
Osteoarthritis 4 97.60 Very High Very High Very High
ischemia 20 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 4 100.00 Very High Very High Very High
Low Back Pain 4 100.00 Very High Very High Very High
Pancreatitis 5 99.96 Very High Very High Very High
Acute-phase Reaction 5 99.92 Very High Very High Very High
Endometriosis (extended) 266 99.78 Very High Very High Very High
Insulin Resistance 45 99.52 Very High Very High Very High
Disease 269 99.40 Very High Very High Very High
INFLAMMATION 507 99.34 Very High Very High Very High
Rheumatic Diseases 8 99.24 Very High Very High Very High
Alzheimer's Dementia 6 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 4 exemplary presents the expression of TLR3 and TLR4 protein in eutopic compared to ectopic endometrium from the same patient.
Negative_regulation (presents) of Gene_expression (expression) of TLR4 protein in endometrium
1) Confidence 0.56 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.43 Pain Relevance 0.11
In mild AP, TLR4 expression increased on the first day of admission and then continued to decline for several days.
Negative_regulation (decline) of Gene_expression (expression) of TLR4 associated with pancreatitis
2) Confidence 0.43 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17415654 Disease Relevance 0.69 Pain Relevance 0.08
In patients with peritoneal endometriosis, TLR3 and TLR4 mRNA expression decreased significantly in proliferative diseased endometrium compared to controls.
Negative_regulation (decreased) of Gene_expression (expression) of TLR4 mRNA in endometrium associated with endometriosis
3) Confidence 0.41 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2543020 Disease Relevance 0.78 Pain Relevance 0.09
controls while significant depression of TLR4 expression was
Negative_regulation (depression) of Gene_expression (expression) of TLR4 associated with depression
4) Confidence 0.41 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 0.47 Pain Relevance 0.53
hypothesized that this polymorphism downregulates TLR4 expression through
Negative_regulation (downregulates) of Gene_expression (expression) of TLR4
5) Confidence 0.41 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.88 Pain Relevance 0
However, we observe locally gained TLR4 expression in epithelial cells as demonstrated in immunohistochemical stainings.
Negative_regulation (gained) of Gene_expression (expression) of TLR4 in epithelial cells
6) Confidence 0.41 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 1.11 Pain Relevance 0.30
In endometriosis, we can observe a significant decrease in TLR3 and TLR4 mRNA levels in eutopic tissues collected during the proliferative phase, when compared to controls (P < 0.05; figure 3A–B).
Negative_regulation (decrease) of Gene_expression (levels) of TLR4 mRNA associated with endometriosis
7) Confidence 0.41 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.32 Pain Relevance 0.08
Interestingly, Th2 cytokines were shown to play an important role in balancing TLR signalling in human intestinal epithelial cells by mediating downregulation of TLR3 and TLR4 expression and function [42].
Negative_regulation (downregulation) of Gene_expression (expression) of TLR4 in epithelial cells associated with cytokine
8) Confidence 0.41 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.67 Pain Relevance 0.34
In addition, we report the expression of TLR4 protein on immune cells such as monocytes and macrophages, in menstrual phase samples (figure 2J).
Negative_regulation (report) of Gene_expression (expression) of TLR4 protein in macrophages
9) Confidence 0.41 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.21 Pain Relevance 0.07
Hepatocytes express TLR4, and respond to LPS by inducing serum amyloid A, cytochrome P450, superoxide dismutase activity, adhesion molecule, TNF-?
Negative_regulation (Hepatocytes) of Gene_expression (express) of TLR4 in Hepatocytes associated with alzheimer's dementia, agonist and adhesions
10) Confidence 0.40 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.52 Pain Relevance 0.40
The expression of TLR4 was significantly reduced in cultured conjunctival and limbal epithelial cells and was even undetectable in some of the cultured cell samples.
Negative_regulation (reduced) of Gene_expression (expression) of TLR4 in epithelial cells
11) Confidence 0.39 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.15 Pain Relevance 0.11
There was a significant reduction in TLR4 mRNA expression following PAF stimulation in those cells pretreated with Tyrphostin AG490 (an indirect STAT3 inhibitor, via JAK2 inhibition), Bay 11–7082 (an inhibitor of NF?
Negative_regulation (reduction) of Gene_expression (expression) of TLR4 mRNA
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
Nevertheless, despite the low expression levels of TLR4 in alveolar macrophages, these cells produced significantly higher (p < 0.05) amounts of IL-1?
Negative_regulation (levels) of Gene_expression (expression) of TLR4 in alveolar macrophages
13) Confidence 0.36 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.05 Pain Relevance 0.04
These results are also compatible with those from Henning et al who reported a significant reduction of TLR2 protein and mRNA, and unaltered TLR4 expression during the in vitro maturation of human monocytes to macrophages in Teflon wells [39].
Negative_regulation (reported) of Gene_expression (expression) of TLR4 in macrophages
14) Confidence 0.36 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.08 Pain Relevance 0.03
These results are also compatible with those from Henning et al who reported a significant reduction of TLR2 protein and mRNA, and unaltered TLR4 expression during the in vitro maturation of human monocytes to macrophages in Teflon wells [39].
Negative_regulation (reduction) of Gene_expression (expression) of TLR4 in macrophages
15) Confidence 0.36 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.08 Pain Relevance 0.03
To assess the expression of TLR2, TLR4 and TLR9 by flow cytometry following ligand exposure, alveolar macrophages and monocytes were stimulated for the optimal incubation periods (described in the Methods section) with Pam3Cys (30 minutes), LPS (10 minutes) and M.tb DNA (24 hours), respectively.
Negative_regulation (assess) of Gene_expression (expression) of TLR4 in alveolar macrophages associated with mycobacterial infection
16) Confidence 0.36 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.09 Pain Relevance 0
Several IEC lines, including the Caco-2 cell line, respond minimally to LPS because of very low TLR4 expression [20], [22], [31].
Negative_regulation (low) of Gene_expression (expression) of TLR4 in Caco-2
17) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.16 Pain Relevance 0
Inverse correlation between HO-1 and TLR4 mRNA in PBMCs from BD patients
Negative_regulation (correlation) of Gene_expression (mRNA) of TLR4 associated with disease
18) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.65 Pain Relevance 0.04
Abnormal expression of TLR4 can predispose to defective HO-1 expression in BD PBMCs, because TLR4 may be a putative HO-1 repressor in hepatic ischemia/reperfusion injury mouse model [35].
Negative_regulation (predispose) of Gene_expression (expression) of TLR4 associated with reperfusion injury, ischemia and disease
19) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.49 Pain Relevance 0.13
treatment decreases local and systemic expression of TLR2 and TLR4 receptors [16, 17].
Negative_regulation (decreases) of Gene_expression (expression) of TLR4
20) Confidence 0.30 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 1.39 Pain Relevance 0.80

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