INT143165

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.50
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (S100a6) nuclear envelope (S100a6) plasma membrane (S100a6)
nucleus (S100a6) cytoplasm (S100a6)
Anatomy Link Frequency
uterus 2
uterine 1
S100a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 6 99.60 Very High Very High Very High
fibrosis 15 60.16 Quite High
Inflammation 9 13.48 Low Low
Potency 12 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 15 99.60 Very High Very High Very High
Cancer 64 99.22 Very High Very High Very High
Pancreatic Cancer 12 99.20 Very High Very High Very High
Ductal Carcinoma 6 98.22 Very High Very High Very High
Pulmonary Fibrosis 9 60.56 Quite High
Malignant Neoplastic Disease 3 57.92 Quite High
Asthma 15 37.76 Quite Low
Pulmonary Disease 3 37.12 Quite Low
Breast Cancer 4 35.24 Quite Low
Cystic Fibrosis 3 34.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S100A6 is increased in a stepwise manner during pancreatic carcinogenesis: clinical value of expression analysis in 98 pancreatic juice samples.
Positive_regulation (increased) of S100A6
1) Confidence 0.69 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Title Doc Link 17416753 Disease Relevance 0.80 Pain Relevance 0.05
Perhaps relatedly, calcyclin (S100A6), another calcium-binding protein, was increased nearly 3-fold at 24 hours post-heparin.
Positive_regulation (increased) of calcyclin
2) Confidence 0.60 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0 Pain Relevance 0
Perhaps relatedly, calcyclin (S100A6), another calcium-binding protein, was increased nearly 3-fold at 24 hours post-heparin.
Positive_regulation (increased) of S100A6
3) Confidence 0.60 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0 Pain Relevance 0
The majority of proteins that were up-regulated were related to calcium signaling and cytoskeletal organization, as evidenced by the strong increases in ANXV and ANXVI, Msn, RhoGDI, PIPTN, calcyclin, and Arp3.
Positive_regulation (increases) of calcyclin
4) Confidence 0.60 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.23 Pain Relevance 0.06
As shown in Fig. 3, the expression level of calcium binding protein A6 (S100a6) in this tissue significantly increased when treated with OP (3.1-fold) and NP (4.2-fold).
Positive_regulation (increased) of S100a6
5) Confidence 0.58 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
E2 resulted in an induction of uterine calcyclin mRNA in immature rats.
Positive_regulation (induction) of calcyclin mRNA in uterine
6) Confidence 0.58 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
In analyses of pancreatic juice, IPMN and pancreatic cancer samples expressed significantly higher levels of S100A6 than did chronic pancreatitis samples (both; P < 0.017), but levels in pancreatic cancer and IPMN samples did not differ form each other.
Positive_regulation (levels) of S100A6 associated with cancer, pancreatic cancer and chronic pancreatitis
7) Confidence 0.47 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17416753 Disease Relevance 1.43 Pain Relevance 0.17
Microdissected invasive ductal carcinoma and intraductal papillary mucinous neoplasm (IPMN) cells expressed significantly higher levels of S100A6 than did microdissected pancreatitis-affected epithelial and normal cells (all comparison; P < 0.008).
Positive_regulation (levels) of S100A6 associated with ductal carcinoma, cancer and pancreatitis
8) Confidence 0.47 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17416753 Disease Relevance 1.05 Pain Relevance 0.06
In parallel with CaBP-9k mRNA, the expression levels of oxytocin (13.4-fold, vs. luteal phase), Acrp30 (3.1-fold, vs. luteal phase), Ldha (3.3-fold, vs. luteal phase), and S100a6 (2.7-fold, vs. luteal phase) mRNAs at follicular phase were up-regulated in this tissue, indicating that they are dominantly expressed during follicular phase and weakly detected at luteal phase in the uterus of mature rats.


Positive_regulation (up) of S100a6 in uterus
9) Confidence 0.34 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
In parallel with CaBP-9k mRNA, the expression levels of oxytocin (13.4-fold, vs. luteal phase), Acrp30 (3.1-fold, vs. luteal phase), Ldha (3.3-fold, vs. luteal phase), and S100a6 (2.7-fold, vs. luteal phase) mRNAs at follicular phase were up-regulated in this tissue, indicating that they are dominantly expressed during follicular phase and weakly detected at luteal phase in the uterus of mature rats.


Positive_regulation (regulated) of S100a6 in uterus
10) Confidence 0.34 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0

General Comments

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