INT14318

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.05
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPT) cell death (MAPT) plasma membrane (MAPT)
cytoskeleton (MAPT) enzyme binding (MAPT) cytoplasm (MAPT)
MAPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 11 100.00 Very High Very High Very High
narcan 4 96.76 Very High Very High Very High
Spinal cord 6 75.00 Quite High
Neurotransmitter 6 75.00 Quite High
substance P 3 75.00 Quite High
Eae 12 73.28 Quite High
opiate 1 58.64 Quite High
tetrodotoxin 4 45.24 Quite Low
excitatory amino acid 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 157 99.84 Very High Very High Very High
Targeted Disruption 46 98.60 Very High Very High Very High
Disease 213 97.76 Very High Very High Very High
Cognitive Disorder 23 92.28 High High
Death 10 90.76 High High
Nociception 8 88.20 High High
Dementia 68 88.00 High High
Amyloid Plaque 20 63.52 Quite High
Affective Disorder 1 38.32 Quite Low
Alzheimer's Dementia 30 36.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreases in Glu, Asn, Gly, and Tau following SP(1-7) infusion were significantly reduced by i.p. or intradialysate naloxone.
Negative_regulation (decreases) of Tau associated with glutamate and narcan
1) Confidence 0.57 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1691775 Disease Relevance 0.28 Pain Relevance 0.56
were crossed with FTDP-17 mutant tau mice [75].
Negative_regulation (crossed) of FTDP-17
2) Confidence 0.07 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.69 Pain Relevance 0.04
However, the CSF t-tau findings are not conclusive, and a contrary report of a decrease in t-tau in DLB was also described in a similar study conducted on autopsy-confirmed sample [61].
Negative_regulation (decrease) of t-tau associated with parkinson's disease
3) Confidence 0.03 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 1.07 Pain Relevance 0

General Comments

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