INT14319

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Context Info
Confidence 0.03
First Reported 1987
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.91
Pain Relevance 3.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SHMT2) methyltransferase activity (SHMT2)
Anatomy Link Frequency
spinal 1
neurons 1
SHMT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 17 100.00 Very High Very High Very High
Glutamate 14 100.00 Very High Very High Very High
Serotonin 4 100.00 Very High Very High Very High
Central grey 18 99.48 Very High Very High Very High
Spinal cord 9 98.52 Very High Very High Very High
Dorsal horn 4 98.04 Very High Very High Very High
cerebral cortex 4 96.84 Very High Very High Very High
Dorsal horn neuron 6 91.40 High High
analgesia 4 89.76 High High
opiate 3 84.32 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 18 99.48 Very High Very High Very High
Nociception 12 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to determine whether PAG stimulation produces the release of serotonin (5-HT), norepinephrine (NE), Gly, and gamma-aminobutyric acid in the spinal cord dorsal horn and whether the release of these neurotransmitters by PAG stimulation is associated with a long-lasting inhibition of the evoked nociceptive responses of dorsal horn neurons.
Localization (release) of Gly in neurons associated with nociception, neurotransmitter, dorsal horn, dorsal horn neuron, serotonin, central grey and spinal cord
1) Confidence 0.03 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215665 Disease Relevance 0.72 Pain Relevance 0.96
Both stimulus frequencies produced a significant increase in the release of 5-HT, NE, Gly, and Asp in the spinal dialysate, but the low-frequency stimulus was more potent in causing the release of neurotransmitters.
Localization (release) of Gly in spinal associated with neurotransmitter
2) Confidence 0.03 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215665 Disease Relevance 0.74 Pain Relevance 1.06
Intradiaylsate infusion of SP(5-11) increased the release of Asp, Glu, asparagine (Asn), glycine (Gly), and taurine (Tau).
Localization (release) of glycine associated with glutamate
3) Confidence 0.00 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1691775 Disease Relevance 0.44 Pain Relevance 0.79
The release of the putative neurotransmitter AAs glutamate (Glu), taurine (Tau), and glycine (Gly) were similarly increased by 50-150% with m-ENK in slices of CS, but not Cx.
Localization (release) of glycine associated with glutamate, neurotransmitter and cerebral cortex
4) Confidence 0.00 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3031217 Disease Relevance 0 Pain Relevance 0.81

General Comments

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