INT143208

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 30
Total Number 32
Disease Relevance 7.54
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (TPI1) cytosol (TPI1) small molecule metabolic process (TPI1)
nucleus (TPI1) embryo development (TPI1) carbohydrate metabolic process (TPI1)
Anatomy Link Frequency
erythrocyte 2
upper 1
TPI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 6 99.46 Very High Very High Very High
Serotonin 16 99.10 Very High Very High Very High
Fibrositis 10 97.50 Very High Very High Very High
anesthesia 30 96.48 Very High Very High Very High
Pain 14 55.48 Quite High
Central nervous system 3 54.68 Quite High
Lasting pain 1 45.20 Quite Low
depression 7 29.44 Quite Low
fibrosis 36 5.00 Very Low Very Low Very Low
Osteoarthritis 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemolytic Anemia 30 99.36 Very High Very High Very High
Aging 82 99.28 Very High Very High Very High
Disease 90 99.26 Very High Very High Very High
Lifespan 18 99.22 Very High Very High Very High
Stress 226 98.68 Very High Very High Very High
Embryonic Lethality 45 98.12 Very High Very High Very High
Fibromyalgia 10 97.50 Very High Very High Very High
Death 40 97.00 Very High Very High Very High
Polycystic Ovary Syndrome 18 96.92 Very High Very High Very High
Infection 27 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result seems to be inconsistent with a previous study based on a German population, in which 3000 persons were screened for reduced TPI activity; 3.7 per 1000 individuals showed reduced triosephosphate isomerase activity (in the range of 39 to 76% compared to the enzyme activity of controls) and were verified to be heterozygous carriers [14]; even higher frequencies of haploid TPI deficiencies were detected in other populations [11-15]).
Negative_regulation (reduced) of TPI
1) Confidence 0.59 Published 2008 Journal BMC Genet Section Body Doc Link PMC2424074 Disease Relevance 0.15 Pain Relevance 0
In fact, a variety of genes increasing the oxidative-stress resistances in model organisms can, dependent on environmental conditions, shorten their lifespan, and yeast as well as C. elegans with reduced TPI activity show indeed shortened lifespan when growing under standard laboratory conditions [17].
Negative_regulation (reduced) of TPI associated with stress and lifespan
2) Confidence 0.51 Published 2008 Journal BMC Genet Section Body Doc Link PMC2424074 Disease Relevance 0.58 Pain Relevance 0
Thus, this result clearly demonstrates that endogenous wild-type TPI is deregulated in the presence of a pathogenic TPI variant exhibiting altered dimerization properties, and hence, one could conclude that this apparent feedback mechanism is potentially accountable for the reduced TPI activity measured in the cell extracts of TPI deficiency patients.


Negative_regulation (reduced) of TPI
3) Confidence 0.51 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762313 Disease Relevance 0.15 Pain Relevance 0
Reduced TPI activity results in increased cellular resistance against the thiol-oxidizing drug diamide
Negative_regulation (Reduced) of TPI
4) Confidence 0.51 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762313 Disease Relevance 0.16 Pain Relevance 0
Since our results seem to be in sharp contrast to the measured TPI activity in unpurified erythrocyte extracts of TPI deficiency patients at disease stage, they clearly make obvious that regulatory events rather than enzyme inactivity are the basis for this enormous reduction in TPI activity.
Negative_regulation (reduction) of TPI in erythrocyte associated with disease
5) Confidence 0.51 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762313 Disease Relevance 0.10 Pain Relevance 0
A drastic decrease in TPI activity and an increased level of its substrate, dihydroxyacetone phosphate, have been measured in unpurified cell extracts of affected individuals.
Negative_regulation (decrease) of TPI
6) Confidence 0.51 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762313 Disease Relevance 0 Pain Relevance 0
A mutagenesis screen in mice identified four heterozygous TPI mutations that lead to a 50% reduction in catalytic TPI activity in several tissues examined [12].
Spec (examined) Negative_regulation (reduction) of TPI
7) Confidence 0.51 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762313 Disease Relevance 0.30 Pain Relevance 0
An association of reduced TPI activity with three allelic variants of the TPI promoter region (located at pos. -5, -8, and -24) in African-Americans [11] could not be confirmed in a follow-up study; these single nucleotide polymorphisms (SNPs) turned out to represent common haplotypes in another African-American sample [16].
Negative_regulation (reduced) of TPI associated with polycystic ovary syndrome
8) Confidence 0.43 Published 2008 Journal BMC Genet Section Body Doc Link PMC2424074 Disease Relevance 0.17 Pain Relevance 0
Moreover, since oxidative stress is a key player in the ageing process – and model organisms with reduced TPI activity are more resistant to it – it is also of viable interest to ascertain the distribution and frequency of allelic TPI variants in humans who have attained an exceptional life span above average.
Negative_regulation (reduced) of TPI associated with stress and aging
9) Confidence 0.43 Published 2008 Journal BMC Genet Section Body Doc Link PMC2424074 Disease Relevance 0.68 Pain Relevance 0
These results are in good agreement with previous observations made in mice showing that a complete lack of TPI activity (homozygous TPI null alleles) causes embryonic lethality at the earliest stages [9].
Negative_regulation (lack) of TPI associated with embryonic lethality
10) Confidence 0.43 Published 2008 Journal BMC Genet Section Body Doc Link PMC2424074 Disease Relevance 0.46 Pain Relevance 0.07
Triosephosphate isomerase deficiency: facts and doubts.
Negative_regulation (deficiency) of Triosephosphate isomerase
11) Confidence 0.43 Published 2006 Journal IUBMB Life Section Title Doc Link 17424909 Disease Relevance 0.18 Pain Relevance 0.09
This finding is exciting since recent studies demonstrated that both compound heterozygous brothers of the Hungarian family have reduced TPI mRNA levels compared to their parents and healthy controls [60] suggesting that altered dimer formation resulting in a modified feedback regulation of the TPI enzyme could underlie the pathogenesis of TPI deficiency.
Negative_regulation (reduced) of TPI
12) Confidence 0.43 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762313 Disease Relevance 0.08 Pain Relevance 0
Thus, this result indicates that a decrease in the catalytic activity of the TPI enzyme mediate cellular resistance against oxidative stress caused by diamide treatment.


Negative_regulation (decrease) of TPI associated with stress
13) Confidence 0.43 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762313 Disease Relevance 0.47 Pain Relevance 0
Finally, it cannot be excluded from our data that inactive TPI alleles have negative effects on human life expectancy and hence, would be depleted in the analyzed LLI group.
Spec (analyzed) Negative_regulation (depleted) of TPI
14) Confidence 0.43 Published 2008 Journal BMC Genet Section Body Doc Link PMC2424074 Disease Relevance 0.43 Pain Relevance 0
One of these, triosephosphate isomerase (TPI) deficiency, is unique among the glycolytic enzyme defects since it is associated with progressive neurological dysfunction and frequently with childhood death.
Negative_regulation (deficiency) of TPI associated with anesthesia and death
15) Confidence 0.42 Published 2006 Journal IUBMB Life Section Abstract Doc Link 17424909 Disease Relevance 0.19 Pain Relevance 0.10
One of these, triosephosphate isomerase (TPI) deficiency, is unique among the glycolytic enzyme defects since it is associated with progressive neurological dysfunction and frequently with childhood death.
Negative_regulation (deficiency) of triosephosphate isomerase associated with anesthesia and death
16) Confidence 0.42 Published 2006 Journal IUBMB Life Section Abstract Doc Link 17424909 Disease Relevance 0.19 Pain Relevance 0.10
The disease pathology correlates with a drastic decrease in the enzymatic activity of TPI and consequently, increased concentration of the TPI substrate dihydroxyacetone phosphate (reviewed in [6,7]).
Negative_regulation (decrease) of TPI associated with disease
17) Confidence 0.38 Published 2008 Journal BMC Genet Section Body Doc Link PMC2424074 Disease Relevance 0.53 Pain Relevance 0.10
Analysis of the pathogenic mutations in a recombinant yeast model revealed that the decrease in TPI activity is not based on an per se inactive enzyme species, but likely the consequence of a misguided regulatory mechanism that might be caused by altered dimerization of the pathogenic TPI isoforms [8].
Negative_regulation (decrease) of TPI
18) Confidence 0.38 Published 2008 Journal BMC Genet Section Body Doc Link PMC2424074 Disease Relevance 0.50 Pain Relevance 0.09
Reduced TPI activity can increase specific oxidant resistances of model organisms and TPI null-alleles have been hypothesized to promote a heterozygote advantage in man.
Negative_regulation (Reduced) of TPI
19) Confidence 0.38 Published 2008 Journal BMC Genet Section Abstract Doc Link PMC2424074 Disease Relevance 0.06 Pain Relevance 0
Remarkably, heterozygous individuals are clinically unaffected, even if their residual TPI activity is reduced to about 50% compared to normal activity [2], [4], [5].
Negative_regulation (reduced) of TPI
20) Confidence 0.37 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762313 Disease Relevance 0.29 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox