INT143230

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 9
Speculated 0
Reported most in Body
Documents 61
Total Number 61
Disease Relevance 52.11
Pain Relevance 15.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
juvenile 2
joint 1
blood 1
synovium 1
foot 1
CRYGD (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 2426 100.00 Very High Very High Very High
cytokine 66 100.00 Very High Very High Very High
Adalimumab 320 99.12 Very High Very High Very High
Infliximab 145 98.96 Very High Very High Very High
Inflammatory response 11 98.36 Very High Very High Very High
Osteoarthritis 55 98.20 Very High Very High Very High
Arthritis 257 97.20 Very High Very High Very High
Fibrositis 32 97.12 Very High Very High Very High
methotrexate 189 97.00 Very High Very High Very High
Inflammation 365 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 2500 100.00 Very High Very High Very High
Disease 963 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 143 99.68 Very High Very High Very High
Disease Progression 20 99.56 Very High Very High Very High
Nicotine Addiction 52 99.24 Very High Very High Very High
Arthropathy 43 99.16 Very High Very High Very High
Increased Venous Pressure Under Development 76 98.92 Very High Very High Very High
Cardiovascular Disease 28 98.72 Very High Very High Very High
Frailty 44 98.20 Very High Very High Very High
Anti-phospholipid Antibody Syndrome 29 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The commercial enzyme-linked immunosorbent assay (ELISA) was used to detect anti-CCP antibodies, including anti-CCP2 (regular, second generation of CCP antigen) and anti-CCP3 (third generation of CCP antigen) in disease-related specimens and normal controls.
Gene_expression (detect) of CCP associated with disease
1) Confidence 0.65 Published 2007 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 17426360 Disease Relevance 2.08 Pain Relevance 0.41
The patients were stratified by the presence of autoantibodies (anti-CCP or RF positive, as one or separate), and HLA-DRB1 SE.
Gene_expression (positive) of CCP
2) Confidence 0.65 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911851 Disease Relevance 0.99 Pain Relevance 0.21
By contrast, anti-CCP was found in six SLE patients, with no difference between those with or without JA (P > 0.05).
Neg (no) Gene_expression (found) of CCP associated with arthropathy and systemic lupus erythematosus
3) Confidence 0.65 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989636 Disease Relevance 1.63 Pain Relevance 0.31
In agreement with our results; Egerer et al24 who studied anti-MCV antibodies in 1151 RA patients, found that anti-MCV antibodies have the same specificity as anti-CCP antibodies but with much better sensitivity (82% versus 72%).
Gene_expression (antibodies) of CCP associated with rheumatoid arthritis
4) Confidence 0.65 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989636 Disease Relevance 1.14 Pain Relevance 0.28
It has been shown that citrulline is the essential antigen epitope recognized by anti-CCP antibodies, antiperinuclear antibodies, as well as antibodies to keratin, filaggrin, and Sa.
Gene_expression (antibodies) of CCP
5) Confidence 0.65 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC2833442 Disease Relevance 1.01 Pain Relevance 0.36
RF and anti-CCP antibodies were more likely to be present in those who subsequently developed into RA.
Gene_expression (antibodies) of CCP associated with rheumatoid arthritis
6) Confidence 0.65 Published 2010 Journal Clin. Rheumatol. Section Abstract Doc Link 19915991 Disease Relevance 0.74 Pain Relevance 0.21
CONCLUSION: Our findings allowed to identify different anatomic foot alterations in RA patients according to disease duration and negative prognostic factors such as anti-CCP antibodies.
Gene_expression (antibodies) of CCP in foot
7) Confidence 0.65 Published 2009 Journal Reumatismo Section Body Doc Link 19370188 Disease Relevance 0.06 Pain Relevance 0
AIMS: We aimed to determine the sensitivity and specificity of anti-CCP antibodies in Indian RA patients with respect to non-RA rheumatic diseases and to study the relationship of anti-CCP antibodies and IgG, IgM and IgA rheumatoid factor in RA.
Gene_expression (antibodies) of CCP
8) Confidence 0.65 Published 2009 Journal Indian J Med Sci Section Body Doc Link 19359776 Disease Relevance 0.18 Pain Relevance 0
Anti-CCP antibodies positive patients did not have more erosive disease in our study.


Gene_expression (antibodies) of CCP
9) Confidence 0.65 Published 2009 Journal Indian J Med Sci Section Body Doc Link 19359776 Disease Relevance 0 Pain Relevance 0
However, the patterns of reactivity for anti-Sa and anti-vimentin are not identical to that of anti-CCP antibodies.
Gene_expression (antibodies) of CCP
10) Confidence 0.65 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989636 Disease Relevance 0.56 Pain Relevance 0.25
The commercial enzyme-linked immunosorbent assay (ELISA) was used to detect anti-CCP antibodies, including anti-CCP2 (regular, second generation of CCP antigen) and anti-CCP3 (third generation of CCP antigen) in disease-related specimens and normal controls.
Gene_expression (generation) of CCP associated with disease
11) Confidence 0.58 Published 2007 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 17426360 Disease Relevance 2.08 Pain Relevance 0.43
The commercial enzyme-linked immunosorbent assay (ELISA) was used to detect anti-CCP antibodies, including anti-CCP2 (regular, second generation of CCP antigen) and anti-CCP3 (third generation of CCP antigen) in disease-related specimens and normal controls.
Gene_expression (generation) of CCP associated with disease
12) Confidence 0.58 Published 2007 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 17426360 Disease Relevance 2.10 Pain Relevance 0.43
Anti-CCP, rheumatoid factor or both?
Gene_expression (rheumatoid factor) of CCP
13) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297585 Disease Relevance 1.17 Pain Relevance 0.17
In three Swedish prospective studies on early RA, disease progression was compared between CCP+ cases and CCP- cases [5,9,10].
Gene_expression (cases) of CCP associated with rheumatoid arthritis and disease progression
14) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297585 Disease Relevance 1.02 Pain Relevance 0.21
Anti-CCP antibodies versus clinical presentation, disease course and outcome
Gene_expression (antibodies) of CCP associated with disease
15) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297585 Disease Relevance 1.29 Pain Relevance 0.32
Anti-CCP, rheumatoid factor or both?
Gene_expression (Anti) of CCP
16) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297585 Disease Relevance 1.16 Pain Relevance 0.17
In three Swedish prospective studies on early RA, disease progression was compared between CCP+ cases and CCP- cases [5,9,10].
Gene_expression (cases) of CCP associated with rheumatoid arthritis and disease progression
17) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297585 Disease Relevance 1.02 Pain Relevance 0.21
Recently, it has been reported that the combination of anti-CCP antibodies and HLA-DRB1 locus antigens is strongly associated with more severe disease progressions [17, 36].
Gene_expression (antibodies) of CCP associated with disease progression
18) Confidence 0.49 Published 2008 Journal Rheumatol Int Section Body Doc Link PMC2493537 Disease Relevance 0.90 Pain Relevance 0.15
Furthermore, we could find no significant difference between anti-CCP negative and anti-CCP-positive patients comparing ESR, CRP, HLA genotype, DAS.
Neg (negative) Gene_expression (negative) of CCP
19) Confidence 0.49 Published 2008 Journal Rheumatol Int Section Body Doc Link PMC2493537 Disease Relevance 0.86 Pain Relevance 0.22
The value of anti-CCP antibodies and RF for predicting the outcome of RA, clinical signs of disease activity, and the severity of radiographic joint damage has been investigated recently.
Gene_expression (antibodies) of CCP in joint associated with rheumatoid arthritis and disease
20) Confidence 0.49 Published 2008 Journal Rheumatol Int Section Body Doc Link PMC2493537 Disease Relevance 1.10 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox