INT143231

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 14.87
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 1
lung 1
CRYGD (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 388 100.00 Very High Very High Very High
Arthritis 24 99.12 Very High Very High Very High
abdominal pain 1 98.60 Very High Very High Very High
Adalimumab 80 97.12 Very High Very High Very High
Inflammatory response 23 96.20 Very High Very High Very High
cva 15 96.12 Very High Very High Very High
Inflammation 173 91.32 High High
Osteoarthritis 49 87.00 High High
spinal inflammation 2 83.16 Quite High
Infliximab 22 83.04 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 395 100.00 Very High Very High Very High
Nicotine Addiction 10 99.98 Very High Very High Very High
Fever 9 99.84 Very High Very High Very High
Disease 120 99.48 Very High Very High Very High
Lung Injury 8 99.16 Very High Very High Very High
Arthritis 21 99.12 Very High Very High Very High
Abdominal Pain 1 98.60 Very High Very High Very High
Sepsis 115 96.96 Very High Very High Very High
Brain Injury 15 96.72 Very High Very High Very High
Syndrome 24 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The commercial enzyme-linked immunosorbent assay (ELISA) was used to detect anti-CCP antibodies, including anti-CCP2 (regular, second generation of CCP antigen) and anti-CCP3 (third generation of CCP antigen) in disease-related specimens and normal controls.
Positive_regulation (generation) of CCP associated with disease
1) Confidence 0.49 Published 2007 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 17426360 Disease Relevance 2.08 Pain Relevance 0.43
The commercial enzyme-linked immunosorbent assay (ELISA) was used to detect anti-CCP antibodies, including anti-CCP2 (regular, second generation of CCP antigen) and anti-CCP3 (third generation of CCP antigen) in disease-related specimens and normal controls.
Positive_regulation (generation) of CCP associated with disease
2) Confidence 0.49 Published 2007 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 17426360 Disease Relevance 2.10 Pain Relevance 0.43
Since serum levels of both anti-MMP3 and anti CCP antibodies were elevated, rheumatoid arthritis (RA) with rheumatoid lung was diagnosed.
Positive_regulation (elevated) of CCP in lung associated with rheumatoid arthritis
3) Confidence 0.45 Published 2010 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20163026 Disease Relevance 1.25 Pain Relevance 0.30
In view of evidence that smoking promotes citrullination of self-proteins, therefore, it has been proposed that smoking promotes anti-CCP in those with at-risk HLA genotypes [60].
Positive_regulation (promotes) of CCP associated with nicotine addiction
4) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.98 Pain Relevance 0.32
Our study showed that the anti-CCP and AFA were highly specific for RA and could be detected up to 23.8% and 17.3% of RF-negative sera, respectively, compared to 35% of Schellekens et al.
Positive_regulation (detected) of anti-CCP associated with rheumatoid arthritis
5) Confidence 0.12 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782206 Disease Relevance 1.05 Pain Relevance 0.36
In our patients, the mean decrease in the PaCO2 by 0.93 kPa led to a mean increase in the CCP of 14 mmHg.
Positive_regulation (increase) of CCP
6) Confidence 0.06 Published 2007 Journal Crit Care Section Body Doc Link PMC2246217 Disease Relevance 0.82 Pain Relevance 0.11
This would have caused a more modest increase in the CCP, and therefore an underestimation of cerebral vasomotor reactivity.
Positive_regulation (increase) of CCP
7) Confidence 0.06 Published 2007 Journal Crit Care Section Body Doc Link PMC2246217 Disease Relevance 0.57 Pain Relevance 0.11
In the present investigation a reduction of the PaCO2 led to a significant increase in the CCP with a consecutive decrease in the VMCA, CBF and SjO2.
Positive_regulation (increase) of CCP
8) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2246217 Disease Relevance 0.87 Pain Relevance 0.08
As expected, the increase in the CCP, and thus cerebral vasomotor tone, was accompanied by a decreased CBF, which is reflected in a reduced VMCA.
Positive_regulation (increase) of CCP
9) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2246217 Disease Relevance 0.48 Pain Relevance 0.03
While the CCP increased from 25 ± 11 mmHg to 39 ± 15 mmHg (P < 0.001), the CBF decreased from 64 ± 29 ml/100 g/min to 39 ± 15 ml/100 g/min (P < 0.001) and the mean SjO2 from 75 ± 8% to 67 ± 14% (P < 0.01).
Positive_regulation (increased) of CCP
10) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2246217 Disease Relevance 0.25 Pain Relevance 0
An additional study with a larger series of anti-CCP-negative patients with RA would be necessary to evaluate such a hypothesis, because the number of anti-CCP-negative patients in the present study was too small.
Positive_regulation (necessary) of anti-CCP associated with rheumatoid arthritis
11) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.56 Pain Relevance 0.33
We likewise observed that O3 exposure caused an increase in serum CCP16 and further showed that pretreatment with either 0.5 mg or 2 mg inhaled FP prevented the O3-induced increase in CCP16.
Positive_regulation (increase) of CCP16
12) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.37 Pain Relevance 0.03
O3 exposure is associated with increased serum levels of CCP16 (Blomberg et al. 2003).
Positive_regulation (increased) of CCP16
13) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.36 Pain Relevance 0.03
CCP16 is induced in the serum of subjects exposed to O3 challenge (Blomberg et al. 2003).
Positive_regulation (induced) of CCP16
14) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.57 Pain Relevance 0.09
Our results showed that serum CCP16 levels were statistically significantly increased after O3 inhalation and that pretreatment with 2 mg FP statistically significantly inhibited this effect compared with placebo (Figure 4).
Positive_regulation (increased) of CCP16
15) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.09 Pain Relevance 0.07
The levels of anti-CCP were increased in RA patients (7.00 ± 4.14 U/ml (mean ± SEM) compared to controls (0.69 ± 0.06 U/ml U/ml) (P < 0.0001) (Figure 3), i.e. approximately 10 times elevated.
Positive_regulation (increased) of anti-CCP associated with rheumatoid arthritis
16) Confidence 0.01 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2426686 Disease Relevance 0.58 Pain Relevance 0.25
Tests for IgM RF and anti-CCP autoantibodies were performed at baseline and after 6 and 12 months of adalimumab treatment.
Positive_regulation (Tests) of anti-CCP associated with adalimumab
17) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.44 Pain Relevance 0.25
Anti-CCP levels increased in FMF patients with arthritis independent from acute phase reactants such as CRP, ESR, and fibrinogen.
Positive_regulation (increased) of Anti-CCP associated with fever and arthritis
18) Confidence 0.00 Published 2010 Journal Rheumatol. Int. Section Abstract Doc Link 19533138 Disease Relevance 1.24 Pain Relevance 0.35
Despite the considerable clinical improvement induced by rituximab treatment, as well as the almost complete depletion of circulating B cells [3,4], only modest, albeit significant, decreases in circulating RF and anti-CCP were observed [5] and levels of these autoantibodies were still highly elevated compared with normal controls.
Positive_regulation (circulating) of anti-CCP in B cells
19) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.14 Pain Relevance 0.07
A small but significant reduction in circulating RF-IgM, anti-CCP IgG, and total IgM, but not total IgG, was observed (Figure 6a).
Positive_regulation (circulating) of anti-CCP
20) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.06 Pain Relevance 0

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