INT143234

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.20
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
astrocytes 1
mononuclear cells 1
Nfkbia (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 860 99.12 Very High Very High Very High
Angina 3 99.04 Very High Very High Very High
Inflammatory response 10 98.66 Very High Very High Very High
Locus ceruleus 5 98.60 Very High Very High Very High
withdrawal 45 92.84 High High
Inflammation 100 92.08 High High
Eae 35 88.24 High High
Pain 6 86.96 High High
Hippocampus 15 86.12 High High
Physical dependence 50 85.20 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 16 99.88 Very High Very High Very High
Cv General 3 Under Development 2 99.04 Very High Very High Very High
INFLAMMATION 103 98.48 Very High Very High Very High
Sprains And Strains 415 97.84 Very High Very High Very High
Respiratory Failure 6 93.76 High High
Pain 9 86.96 High High
Cancer 12 86.84 High High
Death 4 86.64 High High
Metastasis 1 86.08 High High
Drug Dependence 60 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant induction of Nfkbia gene expression after 4 hours was detected in C57BL/6J mice.
Gene_expression (expression) of Nfkbia
1) Confidence 0.62 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.42 Pain Relevance 0.75
This was associated with decreased phosphorylation of NF-kappaB inhibitor protein, IkappaBalpha, and decreased expression of several NFkappaB-regulated genes.
Gene_expression (expression) of IkappaBalpha
2) Confidence 0.57 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.87 Pain Relevance 0.29
Significant interaction was detected for Sgk, Nfkbia, and Hspa1b, for example (Additional data file 1).
Gene_expression (detected) of Nfkbia
3) Confidence 0.54 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.60 Pain Relevance 0.55
Our results indicated that several genes known to be part of the inflammatory response were found downstream of PAR1 activation (b2m, ccl7, cd200, cd63, cdbpd, cfl1, dusp1, fkbp1a, fth1, hspb1, marcksl1, mmp2, myo5a, nfkbia, pax1, plaur, ppia, ptpn1, ptprcap, s100a10, sim2, and tnfaip2).
Gene_expression (cdbpd) of nfkbia associated with inflammatory response
4) Confidence 0.51 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.87 Pain Relevance 0.35
Furthermore, we have identified a relatively large group of genes with parallel expression profiles to that of Tsc22d3 (Sgk, Klf15, Fzd2, Gpt2, Rhpn2, Nt5e, and Nfkbia), which may indicate morphine-induced co-regulation of these genes.
Gene_expression (expression) of Nfkbia associated with morphine
5) Confidence 0.48 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.12 Pain Relevance 0.55
Furthermore, alterations in expression of Sgk and Nfkbia were also observed after acute administration of ethanol [43-45].
Gene_expression (expression) of Nfkbia
6) Confidence 0.48 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.21 Pain Relevance 0.75
Moreover, transcriptional activation of a pattern of co-expressed genes (for instance, Tsc22d3 and Nfkbia) was identified as being mediated via the glucocorticoid receptor (GR).
Gene_expression (expressed) of Nfkbia
7) Confidence 0.48 Published 2007 Journal Genome Biol Section Abstract Doc Link PMC2394777 Disease Relevance 0.46 Pain Relevance 1.12
phosphorylation [14] or exposed transgenic mice expressing a dominant negative NFKBIA (I?
Neg (negative) Gene_expression (expressing) of NFKBIA associated with targeted disruption
8) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.65 Pain Relevance 0.07
In this work, we studied transgenic glial fibrillary acidic protein-IkappaBalpha-dn mice that selectively inactivate the classical nuclear factor kappaB pathway by overexpressing the inhibitory protein of kappaBalpha in astrocytes, under the control of glial fibrillary acidic protein promoter.
Gene_expression (overexpressing) of kappaBalpha in astrocytes associated with targeted disruption
9) Confidence 0.39 Published 2007 Journal Neuroreport Section Abstract Doc Link 17426605 Disease Relevance 0.55 Pain Relevance 0.20
Also, we detected the I-kappaBalpha phosphorylation and the p65NF-kappaB expression in peripheral blood mononuclear cells under our experimental condition.
Gene_expression (expression) of I-kappaBalpha in mononuclear cells
10) Confidence 0.06 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 20346059 Disease Relevance 0.44 Pain Relevance 0.39

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