INT143235

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
astrocytes 2
Nfkbia (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 172 94.56 High High
Pain 5 86.96 High High
Spinal cord 1 76.56 Quite High
Opioid 28 69.76 Quite High
tolerance 8 68.88 Quite High
withdrawal 9 61.40 Quite High
adenocard 2 60.04 Quite High
Physical dependence 10 56.12 Quite High
Inflammation 2 46.72 Quite Low
antagonist 6 26.24 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 97.42 Very High Very High Very High
Sprains And Strains 82 92.88 High High
Pain 4 86.96 High High
Opiate Addiction 8 61.40 Quite High
Drug Dependence 12 56.12 Quite High
Respiratory Failure 1 9.88 Low Low
Hypoxia 1 8.56 Low Low
Shock 8 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Nervous System Malformation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant induction of Nfkbia gene expression after 4 hours was detected in C57BL/6J mice.
Positive_regulation (induction) of Gene_expression (expression) of Nfkbia
1) Confidence 0.56 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.42 Pain Relevance 0.81
In this work, we studied transgenic glial fibrillary acidic protein-IkappaBalpha-dn mice that selectively inactivate the classical nuclear factor kappaB pathway by overexpressing the inhibitory protein of kappaBalpha in astrocytes, under the control of glial fibrillary acidic protein promoter.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of kappaBalpha in astrocytes associated with targeted disruption
2) Confidence 0.29 Published 2007 Journal Neuroreport Section Abstract Doc Link 17426605 Disease Relevance 0.55 Pain Relevance 0.20

General Comments

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