INT143247

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.25
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CAMK4) nucleoplasm (CAMK4) signal transduction (CAMK4)
nucleus (CAMK4) cytoplasm (CAMK4)
Anatomy Link Frequency
neuronal 1
liver 1
cerebral cortex 1
CAMK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 35 99.76 Very High Very High Very High
long-term potentiation 106 98.72 Very High Very High Very High
nMDA receptor 6 98.20 Very High Very High Very High
cerebral cortex 6 96.40 Very High Very High Very High
addiction 16 96.24 Very High Very High Very High
tetrodotoxin 4 92.48 High High
antagonist 6 88.24 High High
Inflammation 49 86.16 High High
Action potential 1 82.96 Quite High
Clonidine 8 76.32 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 23 99.98 Very High Very High Very High
Cv General 3 Under Development 22 99.76 Very High Very High Very High
Death 54 99.24 Very High Very High Very High
Hyperinsulinism 1 98.56 Very High Very High Very High
Infarction 2 97.44 Very High Very High Very High
Stress 4 97.40 Very High Very High Very High
Hemorrhage 43 92.88 High High
Myocardial Infarction 16 91.36 High High
Disorder Of Lipid Metabolism 2 90.12 High High
INFLAMMATION 49 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcium/calmodulin-dependent protein kinase IV, the cAMP-responsive-element binding protein activating enzyme, was also activated by 2,3,7,8-tetrachlorodibenzo-p-dioxin in an activity-dependent manner.
Positive_regulation (activated) of Calcium/calmodulin-dependent protein kinase IV
1) Confidence 0.67 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 17973980 Disease Relevance 0.15 Pain Relevance 0.50
Mechanism of Ca(2+)/calmodulin-dependent protein kinase IV activation and of cyclic AMP response element binding protein phosphorylation during hypoxia in the cerebral cortex of newborn piglets.
Positive_regulation (activation) of Ca(2+)/calmodulin-dependent protein kinase IV in cerebral cortex associated with hypoxia and cerebral cortex
2) Confidence 0.25 Published 2007 Journal Brain Res. Section Title Doc Link 17428448 Disease Relevance 0.63 Pain Relevance 0.33
Previously we showed that hypoxia results in increased neuronal nuclear Ca(2+) influx, Ca(2+)/calmodulin-dependent protein kinase IV activity (CaM KIV) and phosphorylation of c-AMP response element binding (CREB) protein.
Positive_regulation (results) of Ca(2+)/calmodulin-dependent protein kinase IV in neuronal associated with hypoxia
3) Confidence 0.16 Published 2007 Journal Brain Res. Section Abstract Doc Link 17428448 Disease Relevance 0.31 Pain Relevance 0.14
Ca2+ results in the activation of CaMKII (a specific form of CaMK).
Positive_regulation (activation) of CaMK
4) Confidence 0.06 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.59
This so-called Ca2+/CaM complex activates Ca2+/CaM protein kinase (CaMK), which can activate calcium-dependent protein kinase (PKC) as well, but also PKA.
Positive_regulation (activates) of CaMK
5) Confidence 0.06 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0 Pain Relevance 0.03
BDNF-mediated MEK/ERK activation is universally required for gene induction while PI3K, CAMK and NOS activation co-regulate induction on a gene-specific basis
Positive_regulation (activation) of CAMK
6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0 Pain Relevance 0.13
In fasted young animals there is a dramatic increase in liver mRNA synthesis and serum levels of APO A-I and A-IV in response to glucocorticoids and insulin increased by fasting stress [22].
Positive_regulation (increase) of A-IV in liver associated with stress and hyperinsulinism
7) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 0.88 Pain Relevance 0.08
Fatal cerebral hemorrhage: cerebral haemorrhage causing an increase of handicap to Rankin 4 or 5, followed by death.
Positive_regulation (increase) of Rankin 4 associated with cva and death
8) Confidence 0.02 Published 2008 Journal Trials Section Body Doc Link PMC2611963 Disease Relevance 1.82 Pain Relevance 0.19
Fatal cerebral infarction: cerebral infarction causing an increase of handicap to Rankin 4 or 5, followed by death.
Positive_regulation (increase) of Rankin 4 associated with cva and death
9) Confidence 0.02 Published 2008 Journal Trials Section Body Doc Link PMC2611963 Disease Relevance 1.46 Pain Relevance 0.19
Although other downstream calcium-dependent mechanisms have not specifically been addressed in the present study, our results suggest that CAMK and NOS comprise modulatory, rather than universal, regulatory mechanisms of BDNF-mediated gene induction in striatal cells.
Positive_regulation (induction) of CAMK
10) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0 Pain Relevance 0.09

General Comments

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