INT143258

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.16
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr3) signal transduction (Ccr3) extracellular space (Ccr3)
plasma membrane (Ccr3) signal transducer activity (Ccr3)
Anatomy Link Frequency
macrophages 4
brains 2
microglia 2
Ccr3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 73 100.00 Very High Very High Very High
Inflammation 34 98.04 Very High Very High Very High
Neuritis 30 95.90 Very High Very High Very High
cytokine 25 82.32 Quite High
Inflammatory response 9 63.84 Quite High
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 87 99.98 Very High Very High Very High
Malaria 96 99.78 Very High Very High Very High
INFLAMMATION 41 98.04 Very High Very High Very High
Experimental Autoimmune Neuritis 30 95.90 Very High Very High Very High
Adhesions 8 92.92 High High
Brain Disease 4 92.32 High High
Cerebral Malaria 78 83.76 Quite High
Necrosis 4 82.48 Quite High
Cancer 4 82.12 Quite High
Targeted Disruption 21 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tkachuk and colleagues observed that malaria infection induced the expression of CCR3 and CCR5 on placental macrophages in pregnant women [22].
Positive_regulation (induced) of Gene_expression (expression) of CCR3 in macrophages associated with malaria and infection
1) Confidence 0.49 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.55 Pain Relevance 0.20
Compared to wild type EAN mice, TNFR1-/- EAN mice developed significantly more severe clinical signs, in parallel with enhanced numbers of inflammatory infiltrating cells in peripheral nerves and splenic P0-reactive T cell proliferation, as well as increased obviously MHC class II and CCR3 expression on the macrophages in the cauda equina.
Positive_regulation (increased) of Gene_expression (expression) of CCR3 in macrophages associated with inflammation and neuritis
2) Confidence 0.44 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17428547 Disease Relevance 0.70 Pain Relevance 0.62
The expressions of all the C-C chemokine receptors for RANTES, CCR1, CCR3 and CCR5, were upregulated in the brains of P. yoelii 17XL-infected mice.
Positive_regulation (upregulated) of Gene_expression (expressions) of CCR3 in brains associated with chemokine
3) Confidence 0.35 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.55 Pain Relevance 0.41
Increased CC chemokine receptor 3 expression on microglia in apoE-deficient mice after KA administration appeared to facilitate the microglial recruitment and accumulation in the injured areas [90].
Positive_regulation (Increased) of Gene_expression (expression) of chemokine receptor 3 in microglia associated with chemokine
4) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.35 Pain Relevance 0.05

General Comments

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