INT143268

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.09
Pain Relevance 5.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Gprasp1) cytoplasm (Gprasp1)
Anatomy Link Frequency
neurons 2
Gprasp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 23 100.00 Very High Very High Very High
agonist 183 98.68 Very High Very High Very High
Analgesic 190 95.44 Very High Very High Very High
Cannabinoid 178 91.20 High High
tolerance 157 85.44 High High
analgesia 68 82.48 Quite High
cerebral cortex 3 79.36 Quite High
Lasting pain 2 78.28 Quite High
amygdala 3 78.00 Quite High
Hippocampus 9 77.20 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 30 97.92 Very High Very High Very High
Pain 11 78.28 Quite High
Hypothermia 3 70.72 Quite High
Cognitive Disorder 3 53.76 Quite High
Nociception 9 51.12 Quite High
Bordatella Infection 12 46.24 Quite Low
Adhesions 3 20.64 Low Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CB1-GASP1 interaction was observed to be required for agonist-induced downregulation of CB1 in spinal neurons ex vivo as well as in vivo.
CB1-GASP1 Binding (interaction) of in neurons associated with cannabinoid receptor and agonist
1) Confidence 0.48 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17428994 Disease Relevance 0.08 Pain Relevance 1.23
CB1-GASP1 interaction was observed to be required for agonist-induced downregulation of CB1 in spinal neurons ex vivo as well as in vivo.
CB1-GASP1 Binding (interaction) of in neurons associated with cannabinoid receptor and agonist
2) Confidence 0.37 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17428994 Disease Relevance 0.08 Pain Relevance 1.23
Most of the internalized CB1Rs bind to GASP1 and are then degraded in the lysosomal compartment [8,9].
GASP1 Binding (bind) of
3) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.17 Pain Relevance 0.94
Indeed, an important fraction of the internalized receptors is transported to the lysosomal compartment for degradation, and the interaction between CB1Rs and G protein-associated sorting protein 1 (GASP1) plays an essential role in this process [8,9].
GASP1 Binding (interaction) of
4) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.38 Pain Relevance 1.03
Indeed, an important fraction of the internalized receptors is transported to the lysosomal compartment for degradation, and the interaction between CB1Rs and G protein-associated sorting protein 1 (GASP1) plays an essential role in this process [8,9].
protein-associated sorting protein 1 Binding (interaction) of
5) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.38 Pain Relevance 1.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox