INT143270

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.64
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) nucleus (Gprasp1)
plasma membrane (Cnr1) cytoplasm (Gprasp1) signal transducer activity (Cnr1)
Cnr1 (Mus musculus)
Gprasp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 17 100.00 Very High Very High Very High
Cannabinoid 76 99.92 Very High Very High Very High
tolerance 66 97.76 Very High Very High Very High
agonist 68 97.72 Very High Very High Very High
Analgesic 72 95.68 Very High Very High Very High
Cancer pain 1 87.72 High High
Lasting pain 2 84.76 Quite High
analgesia 24 73.92 Quite High
antinociception 11 71.80 Quite High
Pain 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 10 98.16 Very High Very High Very High
Vomiting 1 90.28 High High
Cancer Pain 1 87.72 High High
Pain 5 84.76 Quite High
Hypothermia 1 70.96 Quite High
Ataxia 1 62.00 Quite High
Targeted Disruption 2 56.96 Quite High
Bordatella Infection 4 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show here that the type 1 cannabinoid receptor (CB1) interacts physically with G-protein-associated sorting protein 1 (GASP1), a protein that sorts receptors in lysosomal compartments destined for degradation.
CB1 Binding (interacts) of G-protein-associated sorting protein 1 associated with cannabinoid receptor
1) Confidence 0.54 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17428994 Disease Relevance 0.08 Pain Relevance 1.20
We show here that the type 1 cannabinoid receptor (CB1) interacts physically with G-protein-associated sorting protein 1 (GASP1), a protein that sorts receptors in lysosomal compartments destined for degradation.
CB1 Binding (interacts) of GASP1 associated with cannabinoid receptor
2) Confidence 0.54 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17428994 Disease Relevance 0.08 Pain Relevance 1.21
The cannabinoid 1 (CB1) receptors can be downregulated in vitro through an interaction with the G-protein-coupled receptor-associated sorting protein1, GASP1, that targets CB1 receptors for degradation after their agonist-mediated endocytosis.
CB1 Binding (interaction) of GASP1 associated with cannabinoid and agonist
3) Confidence 0.39 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20164830 Disease Relevance 0.30 Pain Relevance 0.82
Most of the internalized CB1Rs bind to GASP1 and are then degraded in the lysosomal compartment [8,9].
CB1Rs Binding (bind) of GASP1
4) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.17 Pain Relevance 0.94

General Comments

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