INT143271

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
nucleus (Gprasp1) signal transducer activity (Cnr1) cytoplasm (Gprasp1)
Anatomy Link Frequency
neurons 6
Gprasp1 (Mus musculus)
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 14 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
tolerance 10 91.04 High High
Cannabinoid 16 89.68 High High
analgesia 2 88.08 High High
Analgesic 10 83.40 Quite High
Lasting pain 2 78.28 Quite High
Disease Link Frequency Relevance Heat
Pain 2 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CB1-GASP1 interaction was observed to be required for agonist-induced downregulation of CB1 in spinal neurons ex vivo as well as in vivo.
CB1-GASP1 Binding (interaction) of in neurons Positive_regulation (required) of Negative_regulation (downregulation) of CB1 in neurons associated with cannabinoid receptor and agonist
1) Confidence 0.78 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17428994 Disease Relevance 0.08 Pain Relevance 1.26
CB1-GASP1 interaction was observed to be required for agonist-induced downregulation of CB1 in spinal neurons ex vivo as well as in vivo.
CB1-GASP1 Binding (interaction) of in neurons Positive_regulation (required) of Negative_regulation (downregulation) of CB1 in neurons associated with cannabinoid receptor and agonist
2) Confidence 0.56 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17428994 Disease Relevance 0.08 Pain Relevance 1.26

General Comments

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