INT143276

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Context Info
Confidence 0.80
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 42
Total Number 42
Disease Relevance 16.07
Pain Relevance 15.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
spinal 4
spinal cord 3
brain 2
neurons 2
spine 2
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 471 100.00 Very High Very High Very High
Glutamate receptor 320 99.96 Very High Very High Very High
antidepressant 12 99.84 Very High Very High Very High
Lasting pain 202 99.76 Very High Very High Very High
Neuropathic pain 107 99.56 Very High Very High Very High
long-term potentiation 397 99.54 Very High Very High Very High
nMDA receptor 327 99.52 Very High Very High Very High
fluoxetine 3 99.50 Very High Very High Very High
Pain 288 99.44 Very High Very High Very High
Dorsal horn neuron 161 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 293 99.76 Very High Very High Very High
Neuropathic Pain 114 99.56 Very High Very High Very High
Targeted Disruption 459 99.28 Very High Very High Very High
Bone Cancer 41 99.14 Very High Very High Very High
Inflammatory Pain 245 98.80 Very High Very High Very High
Hypersensitivity 55 98.80 Very High Very High Very High
Nociception 693 98.74 Very High Very High Very High
Depression 244 98.68 Very High Very High Very High
INFLAMMATION 254 97.44 Very High Very High Very High
Nervous System Injury 63 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the antidepressant fluoxetine has been found to alter AMPA receptor phosphorylation in a manner that is expected to increase AMPA receptor signaling.
Phosphorylation (phosphorylation) of AMPA receptor associated with antidepressant and fluoxetine
1) Confidence 0.80 Published 2007 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 17430149 Disease Relevance 0.30 Pain Relevance 0.55
The phosphorylation of GluR2 subunit at Serine880 by PKC may lead to disrupt the interaction between GluR2 and GRIP and follow by GluR2 internalization.
Phosphorylation (phosphorylation) of GluR2 associated with kinase c
2) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.61 Pain Relevance 0.56
All these intracellular events triggered by phosphorylation of AMPA receptor subunits may contribute to the enhanced efficacy of glutamatergic synapses (Figure 2).
Phosphorylation (phosphorylation) of AMPA receptor in synapses
3) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.21 Pain Relevance 0.34
The phosphorylation of AMPA receptor subunit may be the most important process because it can trigger or affect other associated processes.
Phosphorylation (phosphorylation) of AMPA receptor subunit
4) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.64 Pain Relevance 0.55
Interestingly, several studies have shown that the trafficking of AMPA receptors, their subunits composition, phosphorylation regulation of AMPA receptor subunits, and interacting proteins also play an important role in the nociceptive processing of the spinal cord.
Phosphorylation (phosphorylation) of AMPA receptor in spinal cord associated with nociception and spinal cord
5) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.42 Pain Relevance 0.46
More specifically, CaMKII may impact the phosphorylation of GluR1 subunit of AMPA receptor at both Serine831 and Serine845 sites in neurons in the spinal cord after strong noxious peripheral stimulation [23].
Phosphorylation (phosphorylation) of AMPA receptor in spinal cord associated with spinal cord
6) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.10 Pain Relevance 0.32
The phosphorylation of GluR2 plays an important role in the receptor clusters during synaptic plasticity and persistent pain.
Phosphorylation (phosphorylation) of GluR2 associated with pain and lasting pain
7) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.35 Pain Relevance 0.60
As an important class of glutamate receptors, phosphorylation of AMPA receptor subunits has been widely investigated in relation to processes of synaptic plasticity in different brain regions.
Phosphorylation (phosphorylation) of AMPA receptor in brain associated with glutamate receptor
8) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.22 Pain Relevance 0.39
It has been demonstrated that phosphorylation of AMPA receptor subunits may potentiate their activity, influence their interaction with intracellular partner proteins, and promote their expression at the plasma membrane during synaptic plasticity [34-37].
Phosphorylation (phosphorylation) of AMPA receptor in plasma
9) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.26 Pain Relevance 0.36
This phosphorylation of GluR2 on Serine880 may further impede the affinity of GluR2 for GRIP, release GluR2 from GRIP-GluR2 complex and finally lead to the internalization of GluR2 subunits.
Phosphorylation (phosphorylation) of GluR2
10) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.35 Pain Relevance 0.21
More specifically, CaMKII may impact the phosphorylation of GluR1 subunit of AMPA receptor at both Serine831 and Serine845 sites in neurons in the spinal cord after strong noxious peripheral stimulation [23].
Phosphorylation (subunit) of AMPA receptor in spinal cord associated with spinal cord
11) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.09 Pain Relevance 0.32
GluR4 is the most rapidly desensitizing subunit of AMPA receptors and is phosphorylated at Serine842, within its C-terminal domain [47].
Phosphorylation (phosphorylated) of AMPA
12) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.53 Pain Relevance 0.29
to AMPA receptors and present a selective phosphorylation site of GluR2 at Serine880 [53-55].
Phosphorylation (phosphorylation) of GluR2
13) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.36 Pain Relevance 0.20
The phosphorylation status of GluR1 and GluR2 subunits modulates the rapid alterations in the composition of synaptic AMPA receptors.
Phosphorylation (phosphorylation) of GluR2
14) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.58 Pain Relevance 0.49
The increased AMPA receptor-mediated synaptic responses may reflect the altered expression or phosphorylation of AMPA receptors in neurabin KO mice [20].
Phosphorylation (phosphorylation) of AMPA associated with targeted disruption
15) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.58 Pain Relevance 0.08
Third, the phosphorylation of AMPA receptor may be altered in neurabin KO mice.
Phosphorylation (phosphorylation) of AMPA associated with targeted disruption
16) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.89 Pain Relevance 0.17
CFA-induced peripheral inflammation could induce synaptic GluR2 internalization in spinal dorsal horn neurons during nociception processing and this internalization might be initiated by the phosphorylation of GluR2 at Serine880 by PKC.
Phosphorylation (phosphorylation) of GluR2 in neurons associated with nociception, kinase c, inflammation and dorsal horn neuron
17) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.96 Pain Relevance 0.62
It has been found that phosphorylation of GluR2 at Serine880 by PKC reduces the affinity of GluR2 for GRIP, thus, released GluR2 from GRIP and promotes the internalization of GluR2 [36].
Phosphorylation (phosphorylation) of GluR2 associated with kinase c
18) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.41 Pain Relevance 0.30
Moreover, preventing CFA-induced spinal GluR2 internalization through targeted mutation of the GluR2 PKC phosphorylation site could reduce CFA-evoked hypersensitivity during the maintenance of nociceptive process.
Phosphorylation (phosphorylation) of GluR2 in spinal associated with nociception, kinase c and hypersensitivity
19) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.35 Pain Relevance 0.34
The AMPA receptors present a unique characteristic in the mechanisms of subunit regulation during LTP (long-term potentiation) and LTD (long-term depression), which are involved in the trafficking, altered composition and phosphorylation of AMPA receptor subunits.
Phosphorylation (phosphorylation) of AMPA receptor associated with depression and long-term potentiation
20) Confidence 0.56 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2823608 Disease Relevance 0.33 Pain Relevance 0.35

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