INT143277

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.91
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
spinal cord 2
brain 2
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 9 99.84 Very High Very High Very High
fluoxetine 2 99.62 Very High Very High Very High
depression 47 97.40 Very High Very High Very High
Spinal cord 10 95.96 Very High Very High Very High
Neurotransmitter 4 93.08 High High
Glutamate 42 92.24 High High
Glutamate receptor 26 92.12 High High
Serotonin 1 85.80 High High
Hippocampus 22 84.88 Quite High
nMDA receptor 51 82.76 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 127 99.48 Very High Very High Very High
Depression 47 97.40 Very High Very High Very High
Nociception 31 97.16 Very High Very High Very High
Urological Neuroanatomy 1 76.84 Quite High
Affective Disorder 1 71.68 Quite High
Ganglion Cysts 3 69.68 Quite High
Nervous System Injury 2 55.88 Quite High
Anxiety Disorder 30 54.16 Quite High
Hypersensitivity 2 53.76 Quite High
Inflammatory Pain 20 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the antidepressant fluoxetine has been found to alter AMPA receptor phosphorylation in a manner that is expected to increase AMPA receptor signaling.
Regulation (alter) of Phosphorylation (phosphorylation) of AMPA receptor associated with antidepressant and fluoxetine
1) Confidence 0.60 Published 2007 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 17430149 Disease Relevance 0.31 Pain Relevance 0.55
Interestingly, several studies have shown that the trafficking of AMPA receptors, their subunits composition, phosphorylation regulation of AMPA receptor subunits, and interacting proteins also play an important role in the nociceptive processing of the spinal cord.
Regulation (regulation) of Phosphorylation (phosphorylation) of AMPA receptor in spinal cord associated with nociception and spinal cord
2) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.42 Pain Relevance 0.46
Third, the phosphorylation of AMPA receptor may be altered in neurabin KO mice.
Spec (may) Regulation (altered) of Phosphorylation (phosphorylation) of AMPA associated with targeted disruption
3) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.89 Pain Relevance 0.17
Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine.
Regulation (Involvement) of Phosphorylation (phosphorylation) of AMPA receptor associated with antidepressant
4) Confidence 0.15 Published 2007 Journal Eur. J. Neurosci. Section Title Doc Link 18088278 Disease Relevance 0.17 Pain Relevance 0.34
It has been shown that AMPA-receptor phosphorylation is critical for synaptic plasticity in the brain [61] and postsynaptically, GluR1 is mainly regulated through changes in CaMKII phosphorylation [62].
Regulation (critical) of Phosphorylation (phosphorylation) of AMPA-receptor in brain
5) Confidence 0.07 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.12 Pain Relevance 0.18
The results is surprising, given that cAMP-PKA pathway is known to modulate AMPA receptor phosphorylation and trafficking [18,45].
Regulation (modulate) of Phosphorylation (phosphorylation) of AMPA
6) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2570662 Disease Relevance 0 Pain Relevance 0.17

General Comments

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