INT143290

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.48
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
spinal cord 3
DRG 1
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 10 100.00 Very High Very High Very High
intrathecal 2 98.60 Very High Very High Very High
Spinal cord 14 97.32 Very High Very High Very High
Sciatic nerve 2 96.68 Very High Very High Very High
Neuropathic pain 6 79.48 Quite High
Peripheral nerve injury 2 78.28 Quite High
cINOD 1 41.60 Quite Low
Pain 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 10 100.00 Very High Very High Very High
Necrosis 6 83.88 Quite High
Cancer 6 83.52 Quite High
Neuropathic Pain 6 79.48 Quite High
Nervous System Injury 2 78.28 Quite High
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal treatment with a TNFR1 antisense oligonucleotide (ASO) significantly inhibited CCI-elevated IKKs phosphorylation, IkB-alpha degradation, the nuclear translocation, phosphorylation, and DNA-binding activity of NF-kappaB, p38 MAPK activation, and IL-6 mRNA and protein expression in the spinal cord and DRG.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of NF-kappaB in spinal cord associated with eae, spinal cord and intrathecal
1) Confidence 0.35 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.24 Pain Relevance 0.87
Intrathecal treatment with a TNFR1 antisense oligonucleotide (ASO) significantly inhibited CCI-elevated IKKs phosphorylation, IkB-alpha degradation, the nuclear translocation, phosphorylation, and DNA-binding activity of NF-kappaB, p38 MAPK activation, and IL-6 mRNA and protein expression in the spinal cord and DRG.
Negative_regulation (inhibited) of in DRG Phosphorylation (phosphorylation) of NF-kappaB in spinal cord associated with eae, spinal cord and intrathecal
2) Confidence 0.12 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938092 Disease Relevance 1.24 Pain Relevance 0.87
We also show that ergolide decreases the degradation and phosphorylation of IkappaB, an inhibitory protein of NF-kappaB, and this effect is accompanied by a simultaneous reduction of IkappaB kinase (IKK) activity.
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of NF-kappaB
3) Confidence 0.09 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17430640 Disease Relevance 0 Pain Relevance 0

General Comments

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