INT1433

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Context Info
Confidence 0.60
First Reported 1977
Last Reported 2004
Negated 10
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 1.70
Pain Relevance 8.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC7)
Anatomy Link Frequency
plasma 3
vessels 1
brain 1
heart 1
superior cervical ganglion 1
MUC7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 22 100.00 Very High Very High Very High
addiction 4 100.00 Very High Very High Very High
Kinase C 9 99.82 Very High Very High Very High
agonist 5 99.70 Very High Very High Very High
tetrodotoxin 6 99.00 Very High Very High Very High
nMDA receptor 15 98.90 Very High Very High Very High
narcan 6 98.88 Very High Very High Very High
ischemia 5 98.32 Very High Very High Very High
local anesthetic 18 97.92 Very High Very High Very High
lidocaine 11 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 5 98.32 Very High Very High Very High
Ganglion Cysts 4 96.92 Very High Very High Very High
Nociception 2 93.08 High High
Pain 1 92.56 High High
Injury 1 91.40 High High
Neuropathic Pain 2 90.00 High High
Decapitation 1 86.76 High High
Toxicity 1 81.88 Quite High
Intellectual Impairment 1 81.12 Quite High
Epilepsy 1 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed that GAA significantly inhibited Na+, K+-ATPase activity without affecting Mg2+-ATPase activity.
Neg (without) Regulation (affecting) of Mg2
1) Confidence 0.60 Published 2004 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 15245754 Disease Relevance 0.16 Pain Relevance 0.10
The studies reviewed herein: compare the effects of several different Ca2+ channel blockers on resistance and capacitance vessels in different regional microvasculatures (i.e., mesenteric, skeletal muscle, pial) within a single species, namely the rat, by high-resolution TV microscopy, and demonstrate the rationale, effects and mechanisms of action of Mg2+ on regional blood vessels.
Regulation (effects) of Mg2 in vessels
2) Confidence 0.38 Published 1984 Journal Microcirc Endothelium Lymphatics Section Abstract Doc Link 6400430 Disease Relevance 0.07 Pain Relevance 0.08
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation.
Regulation (modulation) of Mg2 associated with kinase c
3) Confidence 0.26 Published 1992 Journal Nature Section Title Doc Link 1373227 Disease Relevance 0.35 Pain Relevance 0.70
Mg2+-ATPase activity was not altered by any treatment.
Neg (not) Regulation (altered) of Mg2
4) Confidence 0.26 Published 2001 Journal Neurochem. Res. Section Abstract Doc Link 11885784 Disease Relevance 0 Pain Relevance 0.26
Mg2+-ATPase activity was not altered by the metabolites.
Neg (not) Regulation (altered) of Mg2
5) Confidence 0.26 Published 2001 Journal Neurochem. Res. Section Abstract Doc Link 11874200 Disease Relevance 0.07 Pain Relevance 0.10
Tested compounds did not alter Na+, K+-ATPase and Mg2+-ATPase activities, but except for trolox, prevented the inhibitory effect of homocysteine on Na+, K+-ATPase activity.
Neg (not) Regulation (alter) of Mg2
6) Confidence 0.26 Published 2001 Journal Neurochem. Res. Section Abstract Doc Link 11874200 Disease Relevance 0.07 Pain Relevance 0.12
Na+,K+-ATPase activity was significantly reduced (by 20%) in membranes from the proline-treated group compared to the controls, whereas Mg2+-ATPase activity was not affected by proline.
Neg (not) Regulation (affected) of Mg2
7) Confidence 0.26 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10850553 Disease Relevance 0.09 Pain Relevance 0.19
The small potentials proved to be dependent on Ca2+ and Mg2+ levels in the bath.
Regulation (dependent) of Mg2
8) Confidence 0.23 Published 1977 Journal Brain Res. Section Abstract Doc Link 199319 Disease Relevance 0 Pain Relevance 0.08
Pretreatment of loaded acini with bumetanide, SITS or ouabain had no significant effect on Mg2+ efflux.
Neg (no) Regulation (effect) of Mg2
9) Confidence 0.16 Published 1996 Journal Exp. Physiol. Section Abstract Doc Link 8737071 Disease Relevance 0 Pain Relevance 0.09
The net Mg2+ efflux was not affected by adrenalin, isoproterenol, p-chloromercuribenzenesulfonate, ouabain and tetrodotoxin, but was inhibited by dicyclohexylcarbodiimide, KCN, iodoacetate, high extracellular concentrations of Mg2+, Mn2+ and when extracellular Na+ was substituted by choline or K+.
Neg (not) Regulation (affected) of Mg2 associated with tetrodotoxin
10) Confidence 0.14 Published 1984 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 6422934 Disease Relevance 0 Pain Relevance 0.10
In addition, no distinguishable changes in the voltage-dependent nature and the reversal potential of NMDA receptors occurred in morphine-treated offspring, suggesting no alterations of Mg2+ blockade and ion selectivity to NMDA receptors.
Neg (no) Regulation (alterations) of Mg2 associated with nmda receptor and morphine
11) Confidence 0.09 Published 2000 Journal Hippocampus Section Abstract Doc Link 11153711 Disease Relevance 0 Pain Relevance 1.21
Modulation of the Ca2+, Mg2(+)-ATPase activity of synaptosomal plasma membrane by the local anesthetics dibucaine and lidocaine.
Regulation (Modulation) of Mg2 in plasma associated with lidocaine and local anesthetic
12) Confidence 0.09 Published 1990 Journal J. Neurochem. Section Title Doc Link 2138212 Disease Relevance 0 Pain Relevance 0.51
We have carried out kinetic studies to quantify the effects of these drugs on the different Ca2(+)-dependent and Mg2(+)-dependent ATPase activities of these membranes.
Regulation (effects) of Mg2
13) Confidence 0.09 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2138212 Disease Relevance 0 Pain Relevance 0.35
The effect of a single administration of morphine sulfate (15 mg/kg, s.c. or 30 mg/kg, i.p., 30 min) on Ca2+-stimulated Mg2+-dependent ATPase activity was investigated in synaptosomal plasma membranes (SPM) prepared from rat cortex.
Spec (investigated) Regulation (effect) of Mg2 in plasma associated with morphine
14) Confidence 0.09 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2944993 Disease Relevance 0 Pain Relevance 0.58
Our results support that (1) in the absence of Mg2+, NMDA is the most effective agonist to stimulate [3H]ACh release from striatal slices (2) magnesium effectively antagonized kainate and AMPA stimulation suggesting that at least part of the kainate and AMPA effects might be attributed to glutamate release (3) besides NMDA, kainate receptors showed a more direct involvement in [3H]ACh release control based on the smaller dependence on Mg2+ and less inhibition by TTX and (4) stimulation of ionotropic glutamate receptors may induce long lasting biochemical changes in receptor/ion channel function since the effects of TTX and/or Mg2+ ions on [3H]ACh release were modified by previous exposure of the tissue to agonists.
Regulation (dependence) of Mg2 associated with tetrodotoxin, addiction, glutamate, glutamate receptor and agonist
15) Confidence 0.07 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15196777 Disease Relevance 0 Pain Relevance 0.68
Mg2+-ATPase was not altered either by morphine or by a naloxone-morphine combination.
Neg (not) Regulation (altered) of Mg2 associated with narcan and morphine
16) Confidence 0.06 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2944993 Disease Relevance 0 Pain Relevance 1.11
Effect of amiodarone on Na+-, K+-ATPase and Mg2+-ATPase activities in rat brain synaptosomes.
Regulation (Effect) of Mg2 in brain
17) Confidence 0.04 Published 1986 Journal Cell Biochem. Funct. Section Title Doc Link 2423267 Disease Relevance 0.09 Pain Relevance 0.05
Concentrations of 1,4-benzoquinone that induced Ca2+ release did not affect the activity of the microsomal Ca2+, Mg2+-APTase.
Neg (not) Regulation (affect) of Mg2
18) Confidence 0.04 Published 1999 Journal Toxicol. Lett. Section Abstract Doc Link 10378447 Disease Relevance 0.08 Pain Relevance 0.32
Modulation of this activity by the changes of the membrane potential that are associated with the adsorption of local anesthetics on the synaptosomal plasma membrane is unlikely, on the basis of the weak effect of membrane potential changes on the Ca2+,Mg2(+)-ATPase activity.
Regulation (changes) of Mg2 in plasma associated with local anesthetic
19) Confidence 0.04 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2138212 Disease Relevance 0 Pain Relevance 0.69
Treatment of the perfused heart with either 10-100 microM of either mexiletine or lidocaine during pre-ischemia resulted in an enhancement of post-ischemic contractile recovery, a suppression of changes in tissue Na+, K+, Ca2+ and Mg2+ contents and an attenuation of the release of creatine kinase and ATP metabolites in an almost concentration-dependent manner.
Regulation (changes) of Mg2 in heart associated with ischemia, mexiletine and lidocaine
20) Confidence 0.04 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7713159 Disease Relevance 0.39 Pain Relevance 0.69

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