INT143317

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.90
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
NAc 4
liver 2
poly 2
Dio1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 8 100.00 Very High Very High Very High
dopamine receptor 1 99.68 Very High Very High Very High
Neuropeptide 3 96.36 Very High Very High Very High
substance P 1 95.80 Very High Very High Very High
Dynorphin 1 95.28 Very High Very High Very High
Enkephalin 1 94.84 High High
Cholecystokinin 1 94.24 High High
Dopamine 16 85.52 High High
cocaine 66 81.84 Quite High
Inflammation 6 76.84 Quite High
Disease Link Frequency Relevance Heat
Body Weight 10 99.50 Very High Very High Very High
Targeted Disruption 72 99.24 Very High Very High Very High
Cancer 110 99.16 Very High Very High Very High
Apoptosis 58 98.08 Very High Very High Very High
Skin Cancer 106 85.28 High High
Neuroblastoma 94 85.00 Quite High
INFLAMMATION 6 76.84 Quite High
Disease 7 73.60 Quite High
Death 14 64.28 Quite High
Metastasis 8 43.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite unaltered expression of D1 and D2 dopamine receptors, there were dramatic alterations in striatal mRNAs encoding the neuropeptides substance P, dynorphin, enkephalin and cholecystokinin.
Regulation (unaltered) of Gene_expression (expression) of D1 associated with dynorphin, dopamine receptor, neuropeptide, enkephalin, cholecystokinin and substance p
1) Confidence 0.26 Published 2007 Journal Brain Res. Section Abstract Doc Link 17433807 Disease Relevance 0 Pain Relevance 0.60
On this regard, mean body weight of treated mice was not affected by either D1 or D6 administration and both liver and renal functionality showed to be normal (see Additional file 2 Table S1).
Neg (not) Regulation (affected) of Gene_expression (administration) of D1 in liver associated with body weight
2) Confidence 0.24 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.80 Pain Relevance 0
We found that there was no difference in NAc D1 levels between any of the mGluR5 genotypes (Supporting Information S1), suggesting that changes in NAc D1 content did not contribute to the phenotypes observed in OSS.
Neg (no) Regulation (difference) of Gene_expression (levels) of D1 in NAc associated with nucleus accumbens
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.53 Pain Relevance 0.39
To determine if D1 levels were altered in mGluR5 Het and KO mice, tissue from the nucleus accumbens (NAc) of naïve mice was taken and probed for levels of D1 protein.
Regulation (altered) of Spec (determine) Gene_expression (levels) of D1 in NAc associated with targeted disruption and nucleus accumbens
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.52 Pain Relevance 0.33
It suppresses the expression of cyclin D1, which is deregulated in several types of tumor, and it also induces apoptosis in tumor cells by activating caspase-8, which leads to cleavage of Bid, thus resulting in sequential release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3, cleavage of poly ADP ribose polymerase (PARP) and apoptosis of tumor cells.
Regulation (deregulated) of Gene_expression (expression) of D1 in poly associated with cancer and apoptosis
5) Confidence 0.14 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.04 Pain Relevance 0.08

General Comments

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