INT143324

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccnd3) nucleus (Ccnd3) cell division (Ccnd3)
cytoplasm (Ccnd3)
Anatomy Link Frequency
proximal 1
Ccnd3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 1 59.56 Quite High
Kinase C 3 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 5 98.80 Very High Very High Very High
Cancer 12 95.84 Very High Very High Very High
Thyroid Neoplasm 18 84.56 Quite High
Colon Cancer 3 82.88 Quite High
Familial Adenomatous Polyposis 6 63.52 Quite High
Hyperplasia 6 61.76 Quite High
INFLAMMATION 1 59.32 Quite High
Hypertrophy 8 51.04 Quite High
Toxicity 11 50.00 Quite Low
Stress 6 9.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of Ccnd1, Ccnd3, and Jun mRNA (all transcriptional targets of Wnt signaling) are suggestive of increased risk to human cancer (Behrens 2000; Ishigaki et al. 2002).
Positive_regulation (Up-regulation) of Ccnd3 associated with cancer
1) Confidence 0.35 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.44 Pain Relevance 0
Besides an increase in cyclin D3, no differences were found in expression of regulating proteins in the proximal colon.
Positive_regulation (increase) of cyclin D3 in proximal
2) Confidence 0.04 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17434727 Disease Relevance 0.60 Pain Relevance 0.06

General Comments

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