INT143337

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 23.73
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
B cell 5
podocytes 2
T cells 2
spinal cord 1
brain 1
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 1405 100.00 Very High Very High Very High
Spinal cord 646 98.56 Very High Very High Very High
Neuritis 582 97.80 Very High Very High Very High
imagery 94 97.56 Very High Very High Very High
Multiple sclerosis 385 94.60 High High
cytokine 115 91.20 High High
medulla 70 87.16 High High
unmyelinated 23 74.80 Quite High
Pain 2 71.52 Quite High
Inflammation 391 64.24 Quite High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 4979 100.00 Very High Very High Very High
Optic Neuritis 559 97.80 Very High Very High Very High
Recurrence 2 97.80 Very High Very High Very High
Respiratory Distress 23 97.76 Very High Very High Very High
Demyelinating Disease 185 97.04 Very High Very High Very High
Infection 437 96.24 Very High Very High Very High
Genetic Predisposition To Disease 23 95.36 Very High Very High Very High
Transverse Myelitis 322 95.32 Very High Very High Very High
Hydrocephalus 86 95.20 Very High Very High Very High
Autoimmune Disease 512 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human monoclonal AQP4-specific IgG1 antibodies should be used to generate anti-idiotype reagents that could be used to identify AQP4 IgG1 binding in situ of autopsy tissue.
AQP4 Binding (binding) of
1) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.63 Pain Relevance 0.09
The similarity of the AQP4 protein sequence between humans and these rodents, and the fact that human NMO-IgG binds murine CNS AQP4 further substantiates the feasibility of developing an AQP4-based rodent model of NMO.
AQP4 Binding (binds) of associated with neuromyelitis optica and central nervous system
2) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.43 Pain Relevance 0.20
The reason for this is not known, but may be related to the access of expressed AQP4 in organs and tissues such as in kidney and gut epithelia to serum components or the association of AQP4 with other membrane proteins.


AQP4 Binding (association) of in gut
3) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.08 Pain Relevance 0.13
Based on the quaternary structure of AQP4 in situ and its interactions with other membrane structures it is difficult to envision a model whereby all potential B cell epitopes would have equal access to extracellular NMO-IgG.
AQP4 Binding (interactions) of in B cell associated with neuromyelitis optica
4) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.67 Pain Relevance 0.25
We do not know how efficient murine and rat MHC class II are at binding AQP4 peptides and activating AQP-specific T cells.
AQP4 Binding (binding) of in T cells
5) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.55 Pain Relevance 0.08
In the tetramer model, individual AQP4 subunits are proposed to interact with each other via residues (R108, G157, W231 I239, Y250) in the H4 and H6 helices [25].
AQP4 Binding (interact) of
6) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.12 Pain Relevance 0
NMO-IgG has been shown to bind to AQP4 and confirmed by several labs.
AQP4 Binding (bind) of associated with neuromyelitis optica
7) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.76 Pain Relevance 0
It is interesting the same multi-protein complex that associates with AQP4 and localized it to the membrane in astrocytes is also involved with aggregation and localization of the acetylcholine receptor at the neuromuscular junction [105,106].
AQP4 Binding (associates) of in neuromuscular junction
8) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 2.01 Pain Relevance 0
Does affinity maturation of the anti-AQP4 (B cell or T cell) response have to occur for AQP4-specifc antibodies to bind more inaccessible arrays of AQP4 on astrocyte foot processes in the spinal cord?
AQP4 Binding (bind) of in spinal cord associated with spinal cord
9) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.91 Pain Relevance 0.51
Immunoreactivity of AQP4 both in controls and hydrocephalic rats localised to the basolateral membrane of the ependymal cells lining the ventricular wall, thus confirming conserved polarisation of the AQP4 positive ependymal cells in hydrocephalus.


AQP4 Binding (Immunoreactivity) of in ependymal cells associated with hydrocephalus
10) Confidence 0.37 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.16 Pain Relevance 0.04
The aim was to classify the temporal expression pattern by comparing the brain AQP4 levels with brain water diffusion and lateral ventricular volume at 2 days, 1 week, and 2 weeks after the induction of hydrocephalus.
AQP4 Binding (comparing) of in brain associated with hydrocephalus
11) Confidence 0.37 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.52 Pain Relevance 0.30
Western blot analyses revealed an approximately 30 kDa band immunoreactive for AQP4 protein and confirmed the presence of AQP4 in chicks.
AQP4 Binding (presence) of in band
12) Confidence 0.36 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2254964 Disease Relevance 0.60 Pain Relevance 0
In summary, we conclude that the presence of AQP4 on chick Müller cells is not simply a phenotypic variation without physiologic significance [67].
AQP4 Binding (presence) of
13) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.25 Pain Relevance 0.03
That fact that the biomarker is an autoantibody that recognizes aquaporin 4 (AQP4), a water channel expressed on astrocyte podocytes, has substantially contributed to the hypothesis that NMO is a humorally mediated autoimmune disease.
aquaporin 4 Binding (recognizes) of in podocytes associated with neuromyelitis optica and autoimmune disease
14) Confidence 0.31 Published 2008 Journal Curr Neurol Neurosci Rep Section Abstract Doc Link 18713580 Disease Relevance 1.33 Pain Relevance 0.27
That fact that the biomarker is an autoantibody that recognizes aquaporin 4 (AQP4), a water channel expressed on astrocyte podocytes, has substantially contributed to the hypothesis that NMO is a humorally mediated autoimmune disease.
AQP4 Binding (recognizes) of in podocytes associated with neuromyelitis optica and autoimmune disease
15) Confidence 0.31 Published 2008 Journal Curr Neurol Neurosci Rep Section Abstract Doc Link 18713580 Disease Relevance 1.33 Pain Relevance 0.27
2) Do the different AQP4-expressing tissues and perhaps the membrane structural organization of AQP4 influence NMO-IgG binding efficacy and thus pathogenesis?
AQP4 Binding (binding) of associated with neuromyelitis optica
16) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.96 Pain Relevance 0.34
Priming of AQP4-specific B and T cells
AQP4 Binding (Priming) of in T cells
17) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.24 Pain Relevance 0.33
Pooled sera from the AQP4-peptide immunized mice bind the M1 human isoform and the rat M23 isoform of AQP4 in HEK cells.
AQP4 Binding (bind) of
18) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.92 Pain Relevance 0
While AQP4 cannot associate with other AQPs, it can form heterotetramers of M1 and M23 [20].
AQP4 Binding (associate) of
19) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.30 Pain Relevance 0.03
The influence on the architecture of AQP4 complexes by M23 and other protein elements needs to be understood before the role of anti-AQP4 antibody-mediated internalization of M1 AQP4 can be linked to NMO pathogenesis [30,35,36].
AQP4 Binding (internalization) of associated with neuromyelitis optica
20) Confidence 0.31 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.37 Pain Relevance 0.04

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