INT14334

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Context Info
Confidence 0.58
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 31
Total Number 31
Disease Relevance 18.63
Pain Relevance 11.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
NK cell 3
T cell 3
prefrontal 2
cerebral cortex 2
lymphocyte 2
Il2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 93 100.00 Very High Very High Very High
cytokine 79 100.00 Very High Very High Very High
cerebral cortex 46 100.00 Very High Very High Very High
Analgesic 24 99.98 Very High Very High Very High
narcan 14 99.84 Very High Very High Very High
Central nervous system 2 99.84 Very High Very High Very High
qutenza 12 99.82 Very High Very High Very High
Neuropeptide 3 99.64 Very High Very High Very High
antagonist 12 98.58 Very High Very High Very High
Opioid 39 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 430 100.00 Very High Very High Very High
INFLAMMATION 110 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 6 99.92 Very High Very High Very High
Stress 46 99.74 Very High Very High Very High
Cancer 70 99.68 Very High Very High Very High
Pressure And Volume Under Development 22 99.62 Very High Very High Very High
Necrosis 12 99.40 Very High Very High Very High
Shock 6 99.34 Very High Very High Very High
Schizophrenia 222 99.32 Very High Very High Very High
Disease 61 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These behavioral data are compatible with the data for IL-2 levels, which showed that IL-2 levels in the cerebral cortex of HA OVX rats were significantly decreased by all three dosages of dioscorea, while IL-2 levels in the prefrontal cortex of LA OVX rats were increased by dioscorea at 250 mg/kg/day.
Negative_regulation (decreased) of IL-2 in prefrontal associated with anxiety disorder and cerebral cortex
1) Confidence 0.58 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.07 Pain Relevance 0.18
The present study showed that the anxiogenic effects of 250mg/kg/day of dioscorea in LA OVX rats were accompanied by an increase in IL-2 levels in the prefrontal cortex, while anxiolytic activity in HA OVX rats was accompanied by a decrease in IL-2 levels in the cerebral cortex.
Negative_regulation (decrease) of IL-2 in prefrontal associated with anxiety disorder and cerebral cortex
2) Confidence 0.58 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.96 Pain Relevance 0.37
Pretreatment with the non selective opioid antagonist naloxone (10(-8)mol/L) or a specific kappa opioid antagonist nor binaltorphimine (nor-BNI, 10(-8) mol/L) abolished the inhibitory effect of IL-2 (200 U/ml) on the Ca(2+) (i) transients of cardiomyocytes, whereas the specific delta opioid antagonist naltrindole (10(-6) mol/L) did not abolish the inhibitory effect.
Negative_regulation (effect) of IL-2 in cardiomyocytes associated with antagonist, narcan and opioid
3) Confidence 0.58 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 11930219 Disease Relevance 0.08 Pain Relevance 0.51
The level of IL-2 was decreased significantly after T II treatment only.
Negative_regulation (decreased) of IL-2
4) Confidence 0.56 Published 1995 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 8575048 Disease Relevance 0 Pain Relevance 0.95
After chronic dioscorea treatment, a decrease in anxiety and IL-2 levels was observed in the HA OVX rats.
Negative_regulation (decrease) of IL-2 associated with anxiety disorder
5) Confidence 0.43 Published 2007 Journal Ann Gen Psychiatry Section Abstract Doc Link PMC1971263 Disease Relevance 0.93 Pain Relevance 0.14
The anxiolytic activity of chronic dioscorea treatment correlated with a decrease in IL-2 levels in the cerebral cortex of HA OVX rats.
Negative_regulation (decrease) of IL-2 in cerebral cortex associated with anxiety disorder and cerebral cortex
6) Confidence 0.43 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 1.04 Pain Relevance 0.30
In addition, all three dosages used in this study (250, 750, and 1500 mg/kg/day) significantly decreased IL-2 levels in the cerebral cortex of OVX HA rats compared to vehicle-treated OVX HA rats (p-values < 0.05), but had no effect on levels in the prefrontal cortex (Table 5).


Negative_regulation (decreased) of IL-2 in cerebral cortex associated with anxiety disorder and cerebral cortex
7) Confidence 0.43 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.80 Pain Relevance 0.24
This conclusion conforms to the rapid reversal of edema in patients after cessation of IL-2 therapy.
Negative_regulation (cessation) of IL-2 associated with pressure and volume under development
8) Confidence 0.43 Published 1990 Journal Lymphology Section Abstract Doc Link 2250485 Disease Relevance 0.10 Pain Relevance 0.06
All the effects of IL-2 were blocked by naloxone (1 microM).
Negative_regulation (blocked) of IL-2 associated with narcan
9) Confidence 0.43 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527482 Disease Relevance 0.46 Pain Relevance 0.99
[Possible mechanism of the analgesic effect of interleukin-2 in central nervous system].
Negative_regulation (effect) of interleukin-2 in central nervous system associated with analgesic and central nervous system
10) Confidence 0.43 Published 1996 Journal Sheng Li Xue Bao Section Title Doc Link 9389181 Disease Relevance 0.09 Pain Relevance 0.79
Inhibition of interleukin-2 production and downregulation of IL-2 and transferrin receptors on rat splenic lymphocytes following PAG morphine administration: a role in natural killer and T cell suppression.
Negative_regulation (Inhibition) of IL-2 in T cell associated with urological neuroanatomy and morphine
11) Confidence 0.39 Published 1999 Journal J. Interferon Cytokine Res. Section Title Doc Link 10433363 Disease Relevance 0.43 Pain Relevance 0.64
The serum proinflammatory cytokines IL-1, IL-6 and TNF-a and the serum globulin fraction were elevated in AID rats, parameters which were more or less normalised by melanin treatment in contrast to the reduced serum levels of IL-2 which were not affected.
Negative_regulation (reduced) of IL-2 associated with disease and cytokine
12) Confidence 0.37 Published 1998 Journal Arzneimittelforschung Section Abstract Doc Link 9706378 Disease Relevance 0.98 Pain Relevance 0.40
At concentrations of 5 x 10(-6) and 10(-5) M, it produced a marked increase in CRF release; however, the simultaneous exposure of MBHs to each of these concentrations of NAL plus IL-2 caused a dose-dependent decrease in IL-2-induced CRF release, suggesting that beta-endorphin or other opioid peptides may play a role in IL-2-induced CRF release.
Negative_regulation (decrease) of IL-2-induced associated with narcan and opioid
13) Confidence 0.37 Published 1995 Journal Neuroimmunomodulation Section Abstract Doc Link 8646567 Disease Relevance 0.13 Pain Relevance 0.60
The behavioural and ECoG effects of alpha-interferon, rat interferon and interleukin-2 were blocked in animals pretreated with naloxone.
Negative_regulation (blocked) of interleukin-2 associated with narcan
14) Confidence 0.36 Published 1990 Journal Neuropharmacology Section Abstract Doc Link 1691831 Disease Relevance 0.14 Pain Relevance 0.35
DMPP dose-dependently suppressed the mitogenic responsiveness of splenic T lymphocytes, splenic NK cell activity, and interleukin-2 (IL-2) and gamma-interferon production by stimulated splenocytes.
Negative_regulation (suppressed) of IL-2 in NK cell
15) Confidence 0.36 Published 1993 Journal Brain Behav. Immun. Section Abstract Doc Link 8219413 Disease Relevance 0 Pain Relevance 0.36
DMPP dose-dependently suppressed the mitogenic responsiveness of splenic T lymphocytes, splenic NK cell activity, and interleukin-2 (IL-2) and gamma-interferon production by stimulated splenocytes.
Negative_regulation (suppressed) of interleukin-2 in NK cell
16) Confidence 0.36 Published 1993 Journal Brain Behav. Immun. Section Abstract Doc Link 8219413 Disease Relevance 0 Pain Relevance 0.36
Rats subjected to CMS exhibited a reduction in sucrose intake, 5-HT, 5-HIAA, IL-2, TC, HDLc and LDLc levels, as well as, diminished NK cell and LAK cell activities.
Negative_regulation (reduction) of IL-2 in LAK cell associated with stress and disorder of lipid metabolism
17) Confidence 0.34 Published 2003 Journal Life Sci. Section Abstract Doc Link 14575813 Disease Relevance 0.85 Pain Relevance 0.18
The behavioural and ECoG effects of alpha-interferon, rat interferon and interleukin-2 were blocked in animals pretreated with naloxone.
Negative_regulation (blocked) of interleukin-2 associated with narcan
18) Confidence 0.33 Published 1990 Journal Ann. Ist. Super. Sanita Section Abstract Doc Link 2393221 Disease Relevance 0.14 Pain Relevance 0.35
Increased interleukin-6 and decreased interleukin-2 were found in the supernatants of the pancreatic tissue homogenates of DBTC-induced pancreatitis rats compared with other groups.
Negative_regulation (decreased) of interleukin-2
19) Confidence 0.30 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 17764527 Disease Relevance 0 Pain Relevance 0
We could find the plausible mechanisms for resistance to ulcer recurrence in group III, which were excellent remodeling activity, enrichments of molecular chaperones like heat shock protein 27 (HSP27), significant decreases in inflammatory cytokines like COX-2, IL-2, and TNF-?
Negative_regulation (decreases) of IL-2 associated with inflammation, shock, ulcers, recurrence and cytokine
20) Confidence 0.21 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 2.05 Pain Relevance 0.17

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