INT143422

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.50
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SPINK1)
SPINK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 289 87.92 High High
Inflammation 18 77.44 Quite High
fibrosis 39 76.44 Quite High
Pain 18 5.00 Very Low Very Low Very Low
Bile 18 5.00 Very Low Very Low Very Low
Pain management 9 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 27 99.98 Very High Very High Very High
Pancreatitis 370 99.88 Very High Very High Very High
Disease 72 91.68 High High
INFLAMMATION 15 77.44 Quite High
Fibrosis 3 76.44 Quite High
Death 3 43.84 Quite Low
Autolysis 3 20.44 Low Low
Pancreatic Cancer 48 5.00 Very Low Very Low Very Low
Cystic Fibrosis 36 5.00 Very Low Very Low Very Low
Pain 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic expression of SPINK1 did not hinder trypsinogen activation, but reduced trypsin activity after supramaximal stimulation with cerulein.
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of SPINK1 associated with targeted disruption
1) Confidence 0.39 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.82 Pain Relevance 0.03
The trypsinogen und SPINK1 mutation database
Negative_regulation (The) of Gene_expression (database) of SPINK1
2) Confidence 0.39 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.96 Pain Relevance 0.20
Transgenic expression of rat SPINK1 in mice reduced the severity of experimental secretagogue-induced pancreatitis [68].
Negative_regulation (reduced) of Gene_expression (expression) of SPINK1 associated with targeted disruption and pancreatitis
3) Confidence 0.34 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1774562 Disease Relevance 0.72 Pain Relevance 0
The expression of the wild-type SPINK1 transcript was decreased to 62% of the healthy control in the CP patient carrying the heterozygous [-215G>A; IVS3+2T>C] mutation.
Negative_regulation (decreased) of Gene_expression (expression) of SPINK1
4) Confidence 0.21 Published 2007 Journal Pancreas Section Body Doc Link 17446841 Disease Relevance 0 Pain Relevance 0

General Comments

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