INT143427

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NGFR) endosome (NGFR) nucleoplasm (NGFR)
cytoplasm (NGFR) signal transducer activity (NGFR) cytosol (NGFR)
NGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 96.24 Very High Very High Very High
Inflammation 2 96.00 Very High Very High Very High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 14 100.00 Very High Very High Very High
Reprotox - General 1 2 97.22 Very High Very High Very High
INFLAMMATION 4 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also evaluated whether, like ibuprofen, an up-regulation of p75 NTR is a molecular mechanism that mediates the anti-growth effectiveness of these drugs.
Regulation (regulation) of p75 NTR
1) Confidence 0.26 Published 2008 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 17447067 Disease Relevance 0.78 Pain Relevance 0.35
PURPOSE: Previously, we reported in vitro observations suggesting that ibuprofen is an effective non-prescription non-steroidal anti-inflammatory drug (NSAID) to reduce the survival of human prostate cancer cells (Andrews et al. in Cancer Chemother Pharmacol 502:77-284, 2002), and that this observed effectiveness is mediated by an up-regulation of the p75 NTR tumor suppressor (Khwaja et al. in Cancer Res 646:207-6213, 2004).
Regulation (regulation) of p75 NTR associated with inflammation, cancer, cinod and reprotox - general 1
2) Confidence 0.26 Published 2008 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 17447067 Disease Relevance 0.87 Pain Relevance 0.39

General Comments

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