INT143443

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 10.93
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
Anatomy Link Frequency
macrophages 1
nucleus 1
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 7 98.48 Very High Very High Very High
ischemia 4 90.80 High High
aspirin 7 90.04 High High
Inflammation 98 89.40 High High
Chronic pancreatitis 3 89.40 High High
cytokine 34 87.28 High High
rheumatoid arthritis 137 82.56 Quite High
Opioid 1 80.48 Quite High
adenocard 24 78.96 Quite High
cINOD 2 76.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 349 100.00 Very High Very High Very High
Hypoxia 261 100.00 Very High Very High Very High
Breast Cancer 49 99.88 Very High Very High Very High
Pancreatic Cancer 82 99.78 Very High Very High Very High
Renal Cancer 28 99.68 Very High Very High Very High
Toxoplasmosis 1 99.54 Very High Very High Very High
Solid Tumor 18 99.46 Very High Very High Very High
Wound Healing 10 98.44 Very High Very High Very High
Adenocarcinoma 11 97.84 Very High Very High Very High
Necrosis 16 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The accumulation and nuclear translocation of HIF-1alpha occurred under hypoxia.
Localization (translocation) of HIF-1alpha
1) Confidence 0.78 Published 2007 Journal J. Oral Pathol. Med. Section Body Doc Link 17448139 Disease Relevance 0.14 Pain Relevance 0
Morphine treatment resulted in a significant decrease in the expression and nuclear translocation of HIF-1 alpha with a concurrent suppression in vascular endothelial growth factor (VEGF) synthesis.
Localization (translocation) of HIF-1 alpha associated with morphine
2) Confidence 0.78 Published 2010 Journal Cell. Immunol. Section Abstract Doc Link 20843508 Disease Relevance 0.57 Pain Relevance 0.73
Results obtained using a coculture setup showed that iNOS-derived NO from activated macrophages induced HIF-1alpha stabilization, TFF gene expression, and accelerated wound healing in cultured epithelial cells.
Localization (stabilization) of HIF-1alpha in macrophages associated with wound healing
3) Confidence 0.73 Published 2010 Journal FASEB J. Section Abstract Doc Link 19741170 Disease Relevance 0.24 Pain Relevance 0.21
Immunohistochemical localization of hypoxia inducible factor 1-?
Localization (localization) of hypoxia inducible factor 1 associated with hypoxia
4) Confidence 0.73 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1156920 Disease Relevance 1.18 Pain Relevance 0
Additional studies revealed that Toxoplasma infection rapidly increased the abundance of the HIF1?
Localization (abundance) of HIF associated with toxoplasmosis
5) Confidence 0.68 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.82 Pain Relevance 0.04
Studies in human specimens of pancreatic cancer showed co-localization of VEGF mRNA, which is produced in ductal cancer cells, and HIF-1?
Localization (localization) of HIF-1 associated with cancer and pancreatic cancer
6) Confidence 0.37 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.55 Pain Relevance 0.09
Under hypoxia, HIF1A dimerises with ARNT, allowing translocation into the nucleus for induction of gene expression.
Localization (translocation) of HIF1A in nucleus associated with hypoxia
7) Confidence 0.30 Published 2010 Journal BMC Med Section Body Doc Link PMC2955589 Disease Relevance 0.61 Pain Relevance 0
In solid tumors, intratumoral hypoxia and HIF-1 mediation have been found to be a key angiogenesis triggering event [10].
Localization (mediation) of HIF-1 associated with hypoxia and solid tumor
8) Confidence 0.16 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.27 Pain Relevance 0.04
In breast cancers, the frequency of HIF-1?
Localization (frequency) of HIF-1 associated with breast cancer
9) Confidence 0.14 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.73 Pain Relevance 0
That permitted to specify the set of HIF-1?
Localization (set) of HIF-1
10) Confidence 0.12 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.30 Pain Relevance 0.03
The presence of HIF-1 is a key catalyst and regulator of the delivery of oxygen, because it induces several angiogenic factors identified thus far, such as vascular endothelial growth factors (VEGFs), interleukin-8 (IL-8) and others([74] for review and references therein).
Localization (presence) of HIF-1
11) Confidence 0.12 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.78 Pain Relevance 0.11
In view of the crucial role of HIF-1?
Localization (role) of HIF-1
12) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.34 Pain Relevance 0.11
expression would also be in keeping with the known rapid stabilization and nuclear translocation of HIF-1?
Localization (translocation) of HIF-1
13) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.74 Pain Relevance 0.14
A substantial study of 375 patients investigated the prognostic significance of mTOR pathway components in tumors obtained at nephrectomy, and observed adverse prognostic impact on disease-specific survival of pS6K, PTEN and Akt independent of stage.73 A small study further suggested that pS6K and possibly Akt were predictors of response to temsirolimus for advanced RCC.67,74 However an extension of the study20 of temsirolimus for poor prognosis advanced RCC did not find a correlation between PTEN and HIF-1?
Localization (correlation) of HIF-1 associated with cancer, renal cancer and disease
14) Confidence 0.05 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880340 Disease Relevance 0.65 Pain Relevance 0

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