INT143445

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Context Info
Confidence 0.85
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.14
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
endothelial cells 1
cleavage 1
ECM 1
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 120 97.26 Very High Very High Very High
agonist 1 91.64 High High
cytokine 84 85.24 High High
antagonist 35 84.68 Quite High
imagery 4 80.48 Quite High
Inflammation 56 80.32 Quite High
chemokine 21 67.52 Quite High
Nerve growth factor 38 60.56 Quite High
ischemia 5 52.96 Quite High
Snapping jaw 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 81 99.72 Very High Very High Very High
Hypoxia 23 98.76 Very High Very High Very High
Cancer 159 97.56 Very High Very High Very High
Herpes Simplex Virus 238 97.04 Very High Very High Very High
Increased Venous Pressure Under Development 5 86.12 High High
Diabetic Macular Edema 11 84.68 Quite High
Peripheral Arterial Disease 36 83.20 Quite High
INFLAMMATION 61 80.32 Quite High
Neuroblastoma 1 78.56 Quite High
Ovarian Cancer 23 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
sVEGFR1 may attenuate interstitial matrix-bound VEGF gradients by 10% at most
Protein_catabolism (gradients) of VEGF
1) Confidence 0.85 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.05 Pain Relevance 0
VEGF mRNA isoforms and stability were assessed using RT-PCR and Northern blot analysis respectively.
Protein_catabolism (stability) of VEGF mRNA
2) Confidence 0.66 Published 2007 Journal J. Oral Pathol. Med. Section Body Doc Link 17448139 Disease Relevance 0.17 Pain Relevance 0
In response to hypoxia, VEGF121 and VEGF165 mRNA were both remarkably increased, while there was no change in VEGF mRNA stability.
Protein_catabolism (stability) of VEGF mRNA
3) Confidence 0.66 Published 2007 Journal J. Oral Pathol. Med. Section Body Doc Link 17448139 Disease Relevance 0.14 Pain Relevance 0
Moreover, interstitial proteolytic clearance of soluble or matrix-bound VEGF – e.g., plasmin- and matrix metalloproteinase (MMP)-mediated cleavage of VEGF165 and the respective release of VEGF110 and VEGF113 fragments [95], [146], as well as the intrinsic protein degradation rate of VEGF [147] – was not considered in the current model.
Protein_catabolism (degradation) of VEGF in cleavage associated with metalloproteinase
4) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.28 Pain Relevance 0.14
VEGF-immunoreactive cells were graded in subchondral bone as: 0, none; 1, ?
Neg (none) Protein_catabolism (graded) of VEGF
5) Confidence 0.60 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0 Pain Relevance 0.07
These suggest PO would be able to suppress angiogenic processes in HT-1080 cancer cells as well as in human endothelial cells, especially considering that it has been reported that HT-1080 cell-secreted VEGF, promoted the basement membrane degradation, migration, proliferation and tube formation of endothelial cells [26], although we have not explored further on this due to our focus of study on HUVEC angiogenesis in this report.
Protein_catabolism (degradation) of VEGF in endothelial cells associated with cancer
6) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.32 Pain Relevance 0.04
The concentration of VEGF was significantly lower in all treated groups compared to the control group (p<0.01), but no difference was shown between treated groups.


Protein_catabolism (concentration) of VEGF
7) Confidence 0.56 Published 2010 Journal Korean Journal of Ophthalmology : KJO Section Abstract Doc Link PMC2916105 Disease Relevance 0.26 Pain Relevance 0
One of the mechanisms modulated by COX-2 during carcinogenesis is angiogenesis, presumably through increased production of the most potent and extensively studied pro-angiogenic factor, VEGF [45].
Protein_catabolism (studied) of VEGF
8) Confidence 0.29 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.59 Pain Relevance 0.35
VEGF isoform mRNA expression depends on transcription, splicing, and degradation of mRNA, and protein expression additionally depends upon translational rate and degradation rate.
Protein_catabolism (degradation) of VEGF
9) Confidence 0.23 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.05
stability and VEGF production [25].
Protein_catabolism (stability) of VEGF
10) Confidence 0.19 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.98 Pain Relevance 0.04
It has been suggested that Flt1 may protect VEGF from proteolytic degradation by binding to it in the ECM [33].
Protein_catabolism (degradation) of VEGF in ECM
11) Confidence 0.13 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.44 Pain Relevance 0
VEGF stimulates phosphorylation and redistribution of occludin [19], which is subsequently endocytosed and degraded [47,48].
Protein_catabolism (degraded) of VEGF
12) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.90 Pain Relevance 0.03

General Comments

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