INT143451

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 4.63
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn5a) plasma membrane (Scn5a) transmembrane transport (Scn5a)
Anatomy Link Frequency
neurons 2
Scn5a (Mus musculus)
Pain Link Frequency Relevance Heat
nav1.3 21 100.00 Very High Very High Very High
Nav1.6 1 100.00 Very High Very High Very High
nav1.8 1 100.00 Very High Very High Very High
Nav1.1 1 100.00 Very High Very High Very High
Nav1.2 1 100.00 Very High Very High Very High
fibrosis 220 97.60 Very High Very High Very High
sodium channel 1 75.00 Quite High
Action potential 62 64.40 Quite High
imagery 50 7.44 Low Low
Inflammation 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 41 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 270 98.24 Very High Very High Very High
Fibrosis 190 97.60 Very High Very High Very High
Disease 40 94.24 High High
Heart Arrhythmia 160 93.20 High High
Aging 100 85.04 High High
Sprains And Strains 10 48.64 Quite Low
Heart Rate Under Development 50 39.36 Quite Low
Cardiovascular Disorder Under Development 30 25.00 Low Low
Syncope 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
50% reduction in Nav1.5 protein expression whereas Nav1.5 reduction in mice with a mild phenotype was less pronounced.
Negative_regulation (reduction) of Gene_expression (expression) of Nav1.5 protein
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.54 Pain Relevance 0.18
We investigated the mechanisms of this heterogeneity in a mouse model with heterozygous targeted disruption of Scn5a (Scn5a+/?
Negative_regulation (disruption) of Gene_expression (/) of Scn5a associated with targeted disruption
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824822 Disease Relevance 0.61 Pain Relevance 0
Because distribution of QRS intervals in the Scn5a+/?
Negative_regulation (distribution) of Gene_expression (intervals) of Scn5a
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.61 Pain Relevance 0.19
In old Scn5a+/?
Negative_regulation (old) of Gene_expression (/) of Scn5a
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.66 Pain Relevance 0.17
In 2 others, all Scn5a+/?
Negative_regulation (all) of Gene_expression (/) of Scn5a
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.38 Pain Relevance 0
We investigated the mechanisms of this heterogeneity in a mouse model with heterozygous targeted disruption of Scn5a (Scn5a+/?
Negative_regulation (disruption) of Gene_expression (/) of Scn5a associated with targeted disruption
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824822 Disease Relevance 0.61 Pain Relevance 0
Whatever its mechanism, one consequence of this shift should be that the fraction of Na+ channels available for cardiac depolarization is larger in Scn5a+/?
Negative_regulation (larger) of Gene_expression (/) of Scn5a
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.15 Pain Relevance 0
Our study points to a key similarity between Scn5a+/?
Negative_regulation (similarity) of Gene_expression (/) of Scn5a
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.24 Pain Relevance 0
Because cardiac conduction relies not only on Na+ current, but also on cellular coupling and myocardial architecture, different hypotheses could be evoked to explain Scn5a+/?
Negative_regulation (evoked) of Gene_expression (explain) of Scn5a
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.48 Pain Relevance 0.20
RT-PCR analysis detected Nav1.1, Nav1.2 and Nav1.6, but not Nav1.3, Nav1.4, Nav 1.5 or Nav1.8 Na+ channel alpha subunit gene expression in cultured Purkinje neurons, as observed in vivo.
Neg (not) Negative_regulation (detected) of Gene_expression (expression) of Nav 1.5 in neurons associated with nav1.3, nav1.1, nav1.2, nav1.8 and nav1.6
10) Confidence 0.41 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17448145 Disease Relevance 0.07 Pain Relevance 0.60
Young Scn5a+/?
Negative_regulation (Young) of Gene_expression (/) of Scn5a
11) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.30 Pain Relevance 0

General Comments

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