INT143460

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.12
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb)
plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)
Anatomy Link Frequency
neuronal 2
RVLM 1
hippocampus CA1 1
Cybb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 258 99.08 Very High Very High Very High
Hippocampus 51 99.08 Very High Very High Very High
cerebral cortex 6 98.52 Very High Very High Very High
Pyramidal cell 9 98.44 Very High Very High Very High
depression 6 97.24 Very High Very High Very High
Rostral ventrolateral medulla 7 91.68 High High
anesthesia 13 79.60 Quite High
isoflurane 9 5.00 Very Low Very Low Very Low
Intracerebroventricular 6 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.60 Very High Very High Very High
Cv General 4 Under Development 165 99.08 Very High Very High Very High
Death 57 98.96 Very High Very High Very High
Stress 78 97.42 Very High Very High Very High
Cv Unclassified Under Development 90 97.28 Very High Very High Very High
Depression 2 97.24 Very High Very High Very High
Cardiovascular Disorder Under Development 4 91.32 High High
Heart Rate Under Development 1 83.36 Quite High
Pressure Volume 2 Under Development 1 82.84 Quite High
Pressure And Volume Under Development 3 62.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
production and oxidative stress neuronal damage in the hippocampus and cerebral cortex following cerebral ischemia, as evidenced by studies using a competitive NOX2 inhibitor and NOX2 knockout mice [11], [12].
Negative_regulation (inhibitor) of NOX2 in neuronal associated with targeted disruption, stress, cv general 4 under development, ischemia, hippocampus and cerebral cortex
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.81 Pain Relevance 0.50
Moreover, we show that NADPH oxidase inhibition via the gp91ds-tat NOX2 inhibitor is neuroprotective of hippocampus CA1 pyramidal cells at 7 d after ischemia/reperfusion, further confirming the importance of NADPH oxidase in neuronal cell death in the hippocampus after global cerebral ischemia.
Negative_regulation (inhibitor) of NOX2 in hippocampus CA1 associated with cv general 4 under development, ischemia, pyramidal cell, hippocampus and death
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.79 Pain Relevance 0.40
To confirm the critical role of NADPH oxidase complex formation and in GCI-induced neuronal cell death, we injected male rats with a specific competitive NOX2 inhibitor, gp91ds-tat (100 ng bilaterally icv, 30 min prior to GCI).
Negative_regulation (inhibitor) of NOX2 in neuronal associated with ischemia and death
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.94 Pain Relevance 0.37
Whereas inhibition of NADPH oxidase or knockdown of the gp91(phox) or p47(phox) gene blunted the early phase (60-150 min), coenzyme Q10 or mitochondrial K(ATP) channel inhibitor antagonized the delayed phase (120-240 min) of LPS-induced increase in O2*- production in RVLM and cardiovascular depression.
Negative_regulation (inhibition) of gp91 in RVLM associated with rostral ventrolateral medulla, depression and cardiovascular disorder under development
4) Confidence 0.00 Published 2007 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17448908 Disease Relevance 0.57 Pain Relevance 0.59

General Comments

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